LORMETAZEPAM
- CAS NO.:848-75-9
- Empirical Formula: C16H12Cl2N2O2
- Molecular Weight: 335.18
- MDL number: MFCD00058578
- EINECS: 212-700-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-15 10:44:01
What is LORMETAZEPAM?
Toxicity
The primary manifestation of overdosage ranges from drowsiness to coma and symptoms may include ataxia, hypotension, hypotonia, respiratory depression which may lead to death .
Experimental LD50 values are as follows : Mouse - 780 mg/kg (intraperitoneal), 1790 mg/kg (oral), 10000 mg/kg (subcutaneous). Rat - 6250 mg/kg (intraperitoneal), 10000 mg/kg (oral), 10000 mg/kg (intraperitoneal).
Chemical properties
Pale Green Solid
Originator
Loramet ,Wyeth, W. Germany,1980
The Uses of LORMETAZEPAM
An analog of Lorazepam (L469850). Sedative, hypnotic. Controlled substance (depressant).
Background
Lormatazepam is an orally available benzodiazepine used in the UK for the treatment of short-term insomnia . It is marketed by Auden Mckenzie (Pharma Division) in 0.5 and 1 mg tablet formulations.
Indications
For the treatment of short-term insomnia
Definition
ChEBI: Lormetazepam is a 1,4-benzodiazepinone compound having a methyl substituent at the 1-position, a hydroxy substituent at the 3-position, a 2-chlorophenyl group at the 5-position and a chloro substituent at the 7-position. It has a role as a sedative. It is a 1,4-benzodiazepinone and an organochlorine compound.
Manufacturing Process
To a suspension of 3.4 g of 3-acetoxy-7-chloro-1,3-dihydro-5-(ochlorophenyl)-2H-1,4-benzodiazepin-2-one in 80 ml of alcohol was added 6 ml of 4 N sodium hydroxide. After complete solution had taken place a solid precipitated that redissolved upon the addition of 80 ml of water. The solution was acidified with acetic acid to give white crystals. After recrystallization from alcohol the compound melted at 192°C to 194°C.
Therapeutic Function
Hypnotic
Pharmacokinetics
Lormetazepam is a benzodiazepine which reduces central nervous system (CNS) activity . It produces anxiolytic, muscle relaxant, sedative and hypnotic effects. Because it is a short-acting benzodiapine, it does not produce significant sedation after waking.
Metabolism
Metabolised to an inactive metabolite via glucuronide conjugation
Properties of LORMETAZEPAM
Melting point: | 163-168°C |
Boiling point: | 575.8±50.0 °C(Predicted) |
Density | 1.4463 (rough estimate) |
refractive index | 1.6100 (estimate) |
Flash point: | 9℃ |
storage temp. | Controlled Substance, -20°C Freezer |
solubility | DMSO (Slightly), Methanol (Slightly) |
pka | 11.60±0.40(Predicted) |
form | Solid |
color | Pale Yellow to Pale Green |
Safety information for LORMETAZEPAM
Signal word | Danger |
Pictogram(s) |
Flame Flammables GHS02 Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08 |
GHS Hazard Statements |
H225:Flammable liquids H370:Specific target organ toxicity, single exposure |
Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P311:Call a POISON CENTER or doctor/physician. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
Computed Descriptors for LORMETAZEPAM
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