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HomeProduct name listLevomepromazine hydrochloride

Levomepromazine hydrochloride

Synonym(s):(R)-3-(2-Methoxy-10H-phenothiazin-10-yl)-N,N,2-trimethylpropylamine hydrochloride

Levomepromazine hydrochloride Structural

What is Levomepromazine hydrochloride?

Originator

Levoprome ,Lederle,US,1966

The Uses of Levomepromazine hydrochloride

Analgesic (central nervous system depressant).

Definition

ChEBI: Levomepromazine hydrochloride is a member of phenothiazines.

Manufacturing Process

95% sodamide (2.33 g) is added to a boiling solution of 3- methoxyphenthiazine (12 g) in anhydrous xylene (150 cc) and the mixture is heated with agitation under reflux for 1? hours. A solution of 1- dimethylamino-2-methyl-3-chloropropane (8.2 g) in anhydrous xylene (90 cc) is then run in over a period of 45 minutes while the reaction temperature is maintained and heating under reflux is continued for 18 hours.
After cooling, the reaction mixture is agitated with a mixture of water (40 cc) and a normal solution of methanesulfonic acid (70 cc), the xylene layer is removed and the acid liquors are washed with ether (200 cc). The aqueous phase is then made alkaline with sodium hydroxide (d = 1.33; 10 cc) and the liberated base is extracted with ether. The ethereal solution is dried over anhydrous potassium carbonate and concentrated at normal pressure. On distillation of the residue under reduced pressure 3-(3-methoxy-10- phenthiazinyl)-2-methyl-1-dimethylaminopropane (11.3 g) is obtained, MP 103°C, BP 182° to 191°C/0.15 mm Hg. The hydrochloride prepared in isopropanol melts at about 90°C.

brand name

Nozinan (Aventis).

Therapeutic Function

Analgesic

Properties of Levomepromazine hydrochloride

storage temp.  2-8°C
form  neat

Safety information for Levomepromazine hydrochloride

Computed Descriptors for Levomepromazine hydrochloride

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