LEUPEPTIN HYDROCHLORIDE

Synonym(s):Acetyl-Leu-Leu-Arg-al hydrochloride

CAS NO.：24125-16-4
Empirical Formula: C20H39ClN6O4
Molecular Weight: 463.01
MDL number: MFCD00133457
SAFETY DATA SHEET (SDS)
Update Date: 2023-04-23 13:52:06

What is LEUPEPTIN HYDROCHLORIDE?

Chemical properties

solid

The Uses of LEUPEPTIN HYDROCHLORIDE

Leupeptin Hydrochloride is a protease inhibitor, used in the characterization of macroautophagic flux in vivo using leupeptin-based assay.

What are the applications of Application

Leupeptin hydrochloride is a calpain, cysteine, and protease inhibitor

Biochem/physiol Actions

Inhibitor of serine and cysteine proteases. Inhibits plasmin, trypsin, papain, calpain, and cathepsin B. Does not inhibit pepsin, cathepsins A and D, thrombin, or α-chymotrypsin. Effective concentration 10-100 μM. There have been numerous studies using leupeptin to protect against hearing loss caused by acoustic overstimulation or the ototoxic antibiotic gentamicin. (Loss of cochlear hair cells is believed to be mediated by calpain.)

Properties of LEUPEPTIN HYDROCHLORIDE

storage temp.	-20°C
Stability:	Stable, but store cold. Incompatible with strong bases, strong acids.

Safety information for LEUPEPTIN HYDROCHLORIDE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection.