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HomeProduct name listLEUPEPTIN HYDROCHLORIDE

LEUPEPTIN HYDROCHLORIDE

Synonym(s):Acetyl-Leu-Leu-Arg-al hydrochloride

LEUPEPTIN HYDROCHLORIDE Structural

What is LEUPEPTIN HYDROCHLORIDE?

Chemical properties

solid

The Uses of LEUPEPTIN HYDROCHLORIDE

Leupeptin Hydrochloride is a protease inhibitor, used in the characterization of macroautophagic flux in vivo using leupeptin-based assay.

What are the applications of Application

Leupeptin hydrochloride is a calpain, cysteine, and protease inhibitor

Biochem/physiol Actions

Inhibitor of serine and cysteine proteases. Inhibits plasmin, trypsin, papain, calpain, and cathepsin B. Does not inhibit pepsin, cathepsins A and D, thrombin, or α-chymotrypsin. Effective concentration 10-100 μM. There have been numerous studies using leupeptin to protect against hearing loss caused by acoustic overstimulation or the ototoxic antibiotic gentamicin. (Loss of cochlear hair cells is believed to be mediated by calpain.)

Properties of LEUPEPTIN HYDROCHLORIDE

storage temp.  -20°C
Stability: Stable, but store cold. Incompatible with strong bases, strong acids.

Safety information for LEUPEPTIN HYDROCHLORIDE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.

Computed Descriptors for LEUPEPTIN HYDROCHLORIDE

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