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HomeProduct name listLEUKOTRIENE C4

LEUKOTRIENE C4

Synonym(s):6R-(((R)-2-((S)-4-amino-4-carboxybutanamido)-3-((carboxymethyl)amino)-3-oxopropyl)thio)-5S-hydroxyicosa-7E,9E,11Z,14Z-eicosatetraenoic acid;Leukotriene C₄ - CAS 72025-60-6 - Calbiochem;LTC₄, 5(S)-Hydroxy-6(R)-S-glutathionyl-7- trans-9- trans-11- cis-14- cis-eicosatetraenoic Acid

  • CAS NO.:72025-60-6
  • Empirical Formula: C30H47N3O9S
  • Molecular Weight: 625.77
  • MDL number: MFCD00151079
  • EINECS: 686-872-9
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-18 21:14:07
LEUKOTRIENE C4 Structural

What is LEUKOTRIENE C4?

Description

Leukotriene C4 (LTC4) is the parent cysteinyl leukotriene produced by the LTC4 synthase catalyzed conjugation of glutathione to LTA4. LTC4 is produced by neutrophils, macrophages, mast cells, and by transcellular metabolism in platelets. It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) and exhibits potent smooth muscle contracting activity. LTC4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute allergic hypersensitivity. The concentration of LTC4 required to produce marked contractions of lung parenchymal strips and isolated tracheal rings is about 1 nM.

The Uses of LEUKOTRIENE C4

LTC4 (Leukotriene C4) is a potent agonist for contraction of smooth muscle, wtih many important immunomodulatory functions.

What are the applications of Application

LTC4 (Leukotriene C4) is a potent agonist for contraction of smooth muscle, wtih many important immunomodulatory functions

Definition

ChEBI: A leukotriene that contains cysteine in their structure.

Properties of LEUKOTRIENE C4

Boiling point: 974.3±65.0 °C(Predicted)
Density  1.225±0.06 g/cm3(Predicted)
Flash point: 11 °C
storage temp.  −20°C
solubility  50mg/mL in DMSO, or in DMF
form  Liquid
pka 2.21±0.10(Predicted)
color  Colorless to light yellow

Safety information for LEUKOTRIENE C4

Signal word Danger
Pictogram(s)
ghs
Flame
Flammables
GHS02
ghs
Skull and Crossbones
Acute Toxicity
GHS06
ghs
Health Hazard
GHS08
GHS Hazard Statements H225:Flammable liquids
H370:Specific target organ toxicity, single exposure
Precautionary Statement Codes P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233:Keep container tightly closed.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

Computed Descriptors for LEUKOTRIENE C4

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