LEUKOTRIENE C4

Synonym(s):6R-(((R)-2-((S)-4-amino-4-carboxybutanamido)-3-((carboxymethyl)amino)-3-oxopropyl)thio)-5S-hydroxyicosa-7E,9E,11Z,14Z-eicosatetraenoic acid;Leukotriene C₄ - CAS 72025-60-6 - Calbiochem;LTC₄, 5(S)-Hydroxy-6(R)-S-glutathionyl-7- trans-9- trans-11- cis-14- cis-eicosatetraenoic Acid

CAS NO.：72025-60-6
Empirical Formula: C30H47N3O9S
Molecular Weight: 625.77
MDL number: MFCD00151079
EINECS: 686-872-9
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-23 20:41:25

What is LEUKOTRIENE C4?

Description

Leukotriene C₄ (LTC₄) is the parent cysteinyl leukotriene produced by the LTC₄ synthase catalyzed conjugation of glutathione to LTA₄. LTC₄ is produced by neutrophils, macrophages, mast cells, and by transcellular metabolism in platelets. It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) and exhibits potent smooth muscle contracting activity. LTC₄-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute allergic hypersensitivity. The concentration of LTC₄ required to produce marked contractions of lung parenchymal strips and isolated tracheal rings is about 1 nM.

The Uses of LEUKOTRIENE C4

LTC4 (Leukotriene C4) is a potent agonist for contraction of smooth muscle, wtih many important immunomodulatory functions.

What are the applications of Application

LTC4 (Leukotriene C4) is a potent agonist for contraction of smooth muscle, wtih many important immunomodulatory functions

Definition

ChEBI: A leukotriene that contains cysteine in their structure.

Properties of LEUKOTRIENE C4

Boiling point:	974.3±65.0 °C(Predicted)
Density	1.225±0.06 g/cm3(Predicted)
Flash point:	11 °C
storage temp.	−20°C
solubility	50mg/mL in DMSO, or in DMF
form	Liquid
pka	2.21±0.10(Predicted)
color	Colorless to light yellow

Safety information for LEUKOTRIENE C4

Signal word	Danger
Pictogram(s)	Flame Flammables GHS02 Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08
GHS Hazard Statements	H225:Flammable liquids H370:Specific target organ toxicity, single exposure
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P233:Keep container tightly closed. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.