LE 300
- CAS NO.:274694-98-3
- Empirical Formula: C20H22N2
- Molecular Weight: 290.4
- MDL number: MFCD00951284
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-30 15:45:59
What is LE 300?
Description
LE300 is a dopamine D1-like receptor antagonist (Kis = 1.9 and 7.5 nM in CHO cell membranes expressing human dopamine D1 and D5 receptors, respectively) and antagonist of the serotonin (5-HT) receptor subtype 5-HT2A (pA2 = 8.32 in a rat tail artery assay). It is selective for dopamine D1 and D5 over D2L and D4.4 receptors (Kis = 44.7 and 109 nM, respectively). LE300 inhibits the conditioned avoidance response in the pole-jump test in rats (ED50 = 0.94 mg/kg), which is predictive for antipsychotic-like activity. It also reduces locomotor activity in the open field test in rats (ED50 = 0.74 mg/kg).
The Uses of LE 300
LE 300 is a potent and selective dopamine receptor antagonist.
What are the applications of Application
LE 300 is a potent and selective D1DR receptor antagonist
Definition
ChEBI: LSM-2007 is a member of indoles.
Biological Activity
Potent and selective dopamine D 1 receptor antagonist (K i values are 0.08-1.9 nM and 6-45 nM for D 1 and D 2 receptors respectively). Also displays moderate affinity for the 5-HT 2A receptor (K i = 20 nM). Active in vivo .
storage
Room temperature
Properties of LE 300
Melting point: | >91°C (dec.) |
storage temp. | Store at RT |
solubility | DMSO: 26 mg/mL |
form | solid |
color | Off-White to Pale Beige |
Stability: | Hygroscopic |
Safety information for LE 300
Computed Descriptors for LE 300
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