LDC1267
- CAS NO.：1361030-48-9
- Empirical Formula: C30H26F2N4O5
- Molecular Weight: 560.55
- MDL number: MFCD28385861
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:54:57
What is LDC1267?
Biological Activity
LDC1267 is a highly selective TAM kinase inhibitor with IC50s of <5 nM, 8 nM, and 29 nM for Mer, Tyro3, and Axl, respectively. Low activity against Met, Aurora B, Lck, Src, and CDK8.
in vitro
LDC1267 moderately affected proliferation in 11 of 95 different cell lines with IC50 >5 μM. In NKG2D-activated NK cells, it abrogates the inhibitory effect of Gas6 stimulation.
in vivo
In B16F10 melanoma-bearing mice, LDC1267 (20 mg/kg, ip) potently enhanced anti-metastatic NK cell activity and resisted tumor metabolism without severe cytotoxicity.
Properties of LDC1267
| Boiling point: | 628.4±55.0 °C(Predicted) |
| Density | 1.32±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | insoluble in H2O; insoluble in EtOH; ≥20.75 mg/mL in DMSO |
| form | solid |
| pka | 9.36±0.70(Predicted) |
| color | White to off-white |
Safety information for LDC1267
Computed Descriptors for LDC1267
New Products
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