LACTAMIDE

Synonym(s):DL-Lactic acid amide

CAS NO.：2043-43-8
Empirical Formula: C3H7NO2
Molecular Weight: 89.09
MDL number: MFCD00008017
EINECS: 218-049-3
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-09 19:38:33

What is LACTAMIDE?

The Uses of LACTAMIDE

Lactamide is used as a synthetic raw material in organic chemistry, as an additive in cosmetics, and as a preservative in frozen semen and fertilized eggs in livestock reproduction studies.

Definition

ChEBI:Lactamide is a monocarboxylic acid amide that is lactic acid in which the carboxylic acid group has been converted to the corresponding carboxamide. It is a monocarboxylic acid amide and a secondary alcohol. It is functionally related to a rac-lactic acid.

Synthesis

α-Hydroxy methyl ester (10 mmol, 1.0 equiv) was added into the 100 ml RBF, anda saturated methanol solution of ammonia (20 ml, 38 equiv) was added underthe ice-water bath and stirred overnight. The mixture was concentrated underreduced pressure and in most case Lactamide were obtained in high yields,while in rare occasions purified by flash chromatography.

Properties of LACTAMIDE

Melting point:	73-76 °C(lit.)
Boiling point:	165.17°C (rough estimate)
Density	1.1948 (rough estimate)
refractive index	1.4368 (estimate)
pka	13.34±0.20(Predicted)
form	powder to crystal
color	White to Almost white
Water Solubility	782.20g/L(25 ºC)
CAS DataBase Reference	2043-43-8(CAS DataBase Reference)

Safety information for LACTAMIDE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P312:Call a POISON CENTER or doctor/physician if you feel unwell. P362:Take off contaminated clothing and wash before reuse. P302+P352:IF ON SKIN: wash with plenty of soap and water. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. P405:Store locked up. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P501:Dispose of contents/container to..…