L-Prolinamide

Chemical properties

Crystalline

Description

L-Prolinamide is a chemical compound that has been shown to inhibit the production of proinflammatory cytokines, making it a potential treatment for rheumatoid arthritis and other autoimmune diseases.

The Uses of L-Prolinamide

Proline based organocatalyst.

The Uses of L-Prolinamide

It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff. Also it is a efficient organocatalysts for aldol reactions on water.

The Uses of L-Prolinamide

L-Prolinamide is an important intermediate of synthetic polypeptide and chiral drug, also as the chiral ligand of asymmetry catalysis building-up reactions, is used for Robinson cyclization and Aldol reaction etc.

Definition

ChEBI: The carboxamide derivative of L-proline.

Preparation

Firstly, reacting L-proline as an initial raw material with triphosgene, diphosgene or phosgene in solvents of anhydrous tetrahydrofuran, 1,4-dioxane, dichlormethane, chloroform, acetonitrile and the like to synthesize L-proline carbamyl chloride of an intermediate state; secondly, further condensing in the presence of triethylamine to generate L-proline-N-carboxyl-anhydride; and finally, performing ammonolysis, and thus obtaining the L-prolinamide.