L-HOMOCYSTEINE
Synonym(s):(S)-2-Amino-4-mercaptobutyric acid
- CAS NO.：6027-13-0
- Empirical Formula: C4H9NO2S
- Molecular Weight: 135.18
- MDL number: MFCD00151320
- EINECS: 227-891-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-04-17 13:57:11
What is L-HOMOCYSTEINE?
Chemical properties
Colourless or nearly colourless solid
The Uses of L-HOMOCYSTEINE
L-Homocysteine is the hydrolysis product of adenosine (A280400), a purine nucleoside. Metabolic fate of L-Homocysteine is converted back to L-Methionine( M260440) via tetrahydrofolate.
The Uses of L-HOMOCYSTEINE
L-homocysteine has been used as a supplement in cell culture media.
What are the applications of Application
L-Homocysteine is a useful reference standard for measuring L-Homocysteine levels
Definition
ChEBI: Homocysteine with L configuration.
General Description
L-homocysteine is used to diagnose homocystinuria.
Biochem/physiol Actions
Elevated homocysteine levels in plasma and tissue are associated with brain atrophy in Alzheimer′s disease as well as in healthy eldery subjects. Increased homocysteine is due to deficiencies in vitamin B status, specifically folate, B6 and B12 vitamins, which act as cofactors for enzymes involved in homocysteine metabolism.
Purification Methods
Crystallise L-homocysteine from aqueous EtOH. All operations should be carried out under N2 as the thiol readily oxidizes in air. The acid (3g) is dissolved in freshly boiled H2O (
Properties of L-HOMOCYSTEINE
| Melting point: | 232°C |
| Boiling point: | 299.7±35.0 °C(Predicted) |
| Density | 1.149 (estimate) |
| refractive index | 1.5480 (estimate) |
| storage temp. | -20°C |
| solubility | Aqueous Acid (Sparingly, Heated, Sonicated), Water (Slightly, Heated) |
| form | solid |
| pka | 2.24±0.10(Predicted) |
| color | White to Off-White |
| optical activity | [α]/D 25.5±1.5°, c = 1 in 1 M HCl |
| Stability: | Air Sensitive, Hygroscopic |
| CAS DataBase Reference | 6027-13-0(CAS DataBase Reference) |
Safety information for L-HOMOCYSTEINE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H372:Specific target organ toxicity, repeated exposure H413:Hazardous to the aquatic environment, long-term hazard |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. P501:Dispose of contents/container to..… |
Computed Descriptors for L-HOMOCYSTEINE
| InChIKey | FFFHZYDWPBMWHY-VKHMYHEASA-N |
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