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HomeProduct name listL-Histidine hydrochloride

L-Histidine hydrochloride

Synonym(s):L-Histidine monohydrochloride solution

  • CAS NO.:1007-42-7
  • Empirical Formula: C6H10ClN3O2
  • Molecular Weight: 191.62
  • MDL number: MFCD00066569
  • EINECS: 213-754-2
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-05 19:05:58
L-Histidine hydrochloride Structural

What is L-Histidine hydrochloride?

Purification Methods

The dihydrochloride crystallises from water or aqueous EtOH and is washed with acetone, then diethyl ether. Alternatively convert it to the histidine di-(3,4-dichlorobenzenesulfonate) salt by dissolving 3,4-dichlorobenzenesulfonic acid (1.5g/10mL) in the aqueous histidine solution with warming, and then the solution is cooled in ice. The resulting crystals (m 280o dec) can be recrystallised from 5% aqueous 3,4-dichlorobenzenesulfonic acid, then dried over CaCl2 under vacuum, and washed with diethyl ether to remove Purification of Biochemicals — Amino Acids and Peptides excess reagent. The dihydrochloride can be regenerated by passing the solution through a Dowex-1 (Cl-form) ion-exchange column. The solid is obtained by evaporation of the solution on a steam bath or better in a vacuum. [Greenstein & Winitz, The Amino Acids Vol 3 p 1976 1961, Beilstein 25/16 V 366.]

Properties of L-Histidine hydrochloride

Melting point: 240-245 °C (dec.)
alpha  [α]D20 +7.0~+10.0°(c=2,HCl)
storage temp.  Inert atmosphere,Room Temperature
CAS DataBase Reference 1007-42-7(CAS DataBase Reference)

Safety information for L-Histidine hydrochloride

Computed Descriptors for L-Histidine hydrochloride

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