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HomeProduct name listL-Canavanine sulfate

L-Canavanine sulfate

Synonym(s):L-α-Amino-γ-(guanidinooxy)butyric acid sulfate salt

  • CAS NO.:2219-31-0
  • Empirical Formula: C5H14N4O7S
  • Molecular Weight: 274.25
  • MDL number: MFCD00012618
  • EINECS: 218-728-4
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-31 20:01:59
L-Canavanine sulfate Structural

What is L-Canavanine sulfate?

The Uses of L-Canavanine sulfate

A Nitric Oxide Synthase inhibitor

The Uses of L-Canavanine sulfate

Canavanine sulfate salt has been used:

  • as a translation inhibitor in yeast translation studies
  • as a component of synthetic complete (SC) drop-out medium for screening yeast
  • for screening Saccharomyces cerevisiae in canavanine mutation frequency assay

What are the applications of Application

Canavanine sulfate is an inhibitor of NOS2

Definition

ChEBI: An organic sulfate salt obtained by combining L-canavanine with one molar equivalent of sulfuric acid.

General Description

Canavanine is a homolog of arginine and a non-protein amino acid. It is present in plants like alfalfa, cloves, beans onions and sprouts. Canavanine is synthesized from L-canavaninosuccinic acid and the biosynthetic pathway was first elucidated in jack bean plant.

Biological Activity

NO synthase inhibitor.

Biochem/physiol Actions

Canavanine is a naturally occurring?L-amino acid that competes and interferes with?L-arginine-utilizing enzymes due to its structural similarity with this?L-amino acid. It is a selective inhibitor of inducible nitric oxide synthase (iNOS). It acts as a substrate for arginyl tRNA and is incorporated during protein synthesis leading to aberrant canavanyl proteins. Supplementation with canavanine worsens the alfalfa induced Systemic lupus erythematosus (SLE) like syndrome and its incorporation with endosome and proteasome disrupts the antigen processing.

Purification Methods

Recrystallise the sulfate by dissolving (~1g) in H2O (10mL), and adding with stirring 0.5 to 1.0 volumes of 95% EtOH whereby crystals separate. These are collected, washed with Me2CO/EtOH (1:1) and dried over P2O5 in a vacuum. [Hunt & Thompson Biochemical Preparations 13 416 1971, Feacon & Bell Biochem J 59 221 1955, Beilstein 4 III 1636, 4 IV 3188.]

Properties of L-Canavanine sulfate

Melting point: 160-165 °C (dec.)
storage temp.  2-8°C
solubility  H2O: 100 mg/mL
form  powder
color  white
BRN  6121291
Stability: Hygroscopic
CAS DataBase Reference 2219-31-0(CAS DataBase Reference)
EPA Substance Registry System L-Canavanine sulfate (2219-31-0)

Safety information for L-Canavanine sulfate

Computed Descriptors for L-Canavanine sulfate

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