L-745,870 TRIHYDROCHLORIDE

CAS NO.：158985-00-3
Empirical Formula: C18H19ClN4
Molecular Weight: 326.82
MDL number: MFCD00932830
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-23 13:36:13

What is L-745,870 TRIHYDROCHLORIDE?

The Uses of L-745,870 TRIHYDROCHLORIDE

L-745,870 is a drug which acts as a dopamine receptor antagonist selective for the D4 subtype, and has antipsychotic effects in animal models, though it was not effective in human trials.

Definition

ChEBI: 3-[[4-(4-chlorophenyl)-1-piperazinyl]methyl]-1H-pyrrolo[2,3-b]pyridine is a member of piperazines.

Biological Activity

A highly potent and selective D 4 dopamine receptor antagonist; L-745,870 has K i values of 0.51, 2300 and 960 nM for D 4 , D 3 and D 2 subtypes respectively and > 1000-fold selectivity over 5-HT 2 , D 1 and D 5 receptors.

Properties of L-745,870 TRIHYDROCHLORIDE

Boiling point:	571.4±50.0 °C(Predicted)
Density	1.31±0.1 g/cm3(Predicted)
storage temp.	Desiccate at +4°C
solubility	DMSO:16.5(Max Conc. mg/mL);50.49(Max Conc. mM)
pka	8.20±0.20(Predicted)
form	Solid
color	White to off-white

Safety information for L-745,870 TRIHYDROCHLORIDE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.