L-3,4-DIHYDROXYPHENYLALANINE METHYL ESTER HYDROCHLORIDE
Synonym(s):Methyl L -DOPA hydrochloride
- CAS NO.:1421-65-4
- Empirical Formula: C10H14ClNO4
- Molecular Weight: 247.68
- MDL number: MFCD00038958
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-01-22 14:59:28
What is L-3,4-DIHYDROXYPHENYLALANINE METHYL ESTER HYDROCHLORIDE?
Description
L-DOPA (Item No. 13248) is a metabolic precursor of dopamine that is capable of crossing the blood brain barrier to act as a dopamine D1 receptor agonist. It is produced from L-tyrosine by trysosine hydroxylase. In the brain, L-DOPA is converted to dopamine by the enzyme aromatic L-amino acid decarboxylase. It is conventionally used to increase dopamine concentrations in the brain as a treatment for Parkinson’s disease and stroke recovery. L-DOPA methyl ester is a neutral derivative of L-DOPA formulated for increased solubility compared to the parent compound.
Chemical properties
White Solid
The Uses of L-3,4-DIHYDROXYPHENYLALANINE METHYL ESTER HYDROCHLORIDE
L-3,4-Dihydroxyphenylalanine methyl ester hydrochloride has been used:
- in treating 6-hydroxydopamine induced lesions mice serotonin neurons
- in tyrosinase activity in B16F10 skin melanoma cells
- to test its neuroprotective effect in mesencephalic neurons
The Uses of L-3,4-DIHYDROXYPHENYLALANINE METHYL ESTER HYDROCHLORIDE
Selective Dopamine D1 receptor agonist.
The Uses of L-3,4-DIHYDROXYPHENYLALANINE METHYL ESTER HYDROCHLORIDE
Precursor to L-DOPA that crosses the blood-brain barrier; antiparkinsonian agent.
What are the applications of Application
L-3,4-Dihydroxyphenylalanine methyl ester hydrochloride is a precursor to L-DOPA that crosses blood-brain barrier
Biochem/physiol Actions
L-3,4-Dihydroxyphenylalanine methyl ester is a precursor to?L-DOPA that crosses the blood-brain barrier. Antiparkinsonian agent L-DOPA methyl ester elicits antitumor functionality in leukemia and melanoma.
in vitro
l-dopa methyl ester is a neutral derivative of l-dopa formulated for increased solubility compared to the parent compound. l-dopa is a metabolic precursor of dopamine that is capable of crossing the blood brain barrier to act as a dopamine d1 receptor agonist [1].
in vivo
on intraperitoneal or subcutaneous administration to mice l-dopa methyl ester was found to be equivalent to l-dopa in reversing reserpine-induced akinesia and producing contraversive circling behaviour in rats. on oral administration the methyl ester was even more active. the administration of l-dopa or the methyl ester had equivalent changes of metabolite levels in striatal and mesolimbic dopamine, homovanillic acid, as well as 3,4-dihydroxyphenylacetic acid [2].
storage
-20°C
References
[1] berends, h. i.,nijlant, j.m.m.,movig, k.l.l., et al. the clinical use of drugs influencing neurotransmitters in the brain to promote motor recovery after stroke; a cochrane systematic review. european journal of physical and rehabilitation medicine 45(4), 621-630 (2009).
[2] cooper dr, marrel c, testa b, van de waterbeemd h, quinn n, jenner p, marsden cd. l-dopa methyl ester--a candidate for chronic systemic delivery of l-dopa in parkinson's disease. clin neuropharmacol. 1984;7(1):89-98.
[3] kleedorfer, b. ,lees, a.j. and stern, g.m. subcutaneous and sublingual levodopa methyl ester in parkinson’s disease. j.neurol.neurosurg.psychiatry 54(4), 373 (1991).
Properties of L-3,4-DIHYDROXYPHENYLALANINE METHYL ESTER HYDROCHLORIDE
Melting point: | 174-175℃ |
alpha | +9.0° to +11.0° (20°C, 589nm) (C=2 in methanol) |
storage temp. | -20°C |
solubility | DMSO (Slightly), Methanol (Slightly) |
form | solid |
color | white |
InChI | InChI=1/C10H13NO4.ClH/c1-15-10(14)7(11)4-6-2-3-8(12)9(13)5-6;/h2-3,5,7,12-13H,4,11H2,1H3;1H/t7-;/s3 |
Safety information for L-3,4-DIHYDROXYPHENYLALANINE METHYL ESTER HYDROCHLORIDE
Computed Descriptors for L-3,4-DIHYDROXYPHENYLALANINE METHYL ESTER HYDROCHLORIDE
InChIKey | WFGNJLMSYIJWII-WMASNCOMNA-N |
SMILES | C1(=CC=C(O)C(O)=C1)C[C@H](N)C(=O)OC.Cl |&1:9,r| |
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