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HomeProduct name listEthyl methyldopate hydrochloride

Ethyl methyldopate hydrochloride

  • CAS NO.:2508-79-4
  • Empirical Formula: C12H18ClNO4
  • Molecular Weight: 275.73
  • MDL number: MFCD07787407
  • EINECS: 219-720-3
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-28 23:16:16
Ethyl methyldopate hydrochloride Structural

What is Ethyl methyldopate hydrochloride?

The Uses of Ethyl methyldopate hydrochloride

Ethyl methyldopate hydrochloride is Antihypertensive.

brand name

Aldomet (Merck).

General Description

Methyldopatehydrochloride, L-3-(3,4-dihydroxyphenyl)-2-methylalanineethyl ester hydrochloride (Aldomet ester hydrochloride), α-methyldopa, lowers blood pressure by inhibitingthe outflow of sympathetic vasoconstrictor impulses fromthe brain. Early studies had suggested that the hypotensiveaction of α-methyldopa was a result of the peripheral propertiesof the drug as a decarboxylase inhibitor or a falsetransmitter.

Clinical Use

Ethyl methyldopate hydrochloride is used as a step 2 agent and is recommendedfor patients with high blood pressure who are not responsiveto diuretic therapy alone. Ethyl methyldopate hydrochloride, suitable for oral use,is a zwitterion and is not soluble enough for parenteral use.The problem was solved by making the ester, leaving theamine free to form the water-soluble hydrochloride salt. It issupplied as a stable, buffered solution, protected with antioxidantsand chelating agents.

Safety information for Ethyl methyldopate hydrochloride

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