Ethyl methyldopate hydrochloride
- CAS NO.:2508-79-4
- Empirical Formula: C12H18ClNO4
- Molecular Weight: 275.73
- MDL number: MFCD07787407
- EINECS: 219-720-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-28 23:16:16
What is Ethyl methyldopate hydrochloride?
The Uses of Ethyl methyldopate hydrochloride
Ethyl methyldopate hydrochloride is Antihypertensive.
brand name
Aldomet (Merck).
General Description
Methyldopatehydrochloride, L-3-(3,4-dihydroxyphenyl)-2-methylalanineethyl ester hydrochloride (Aldomet ester hydrochloride), α-methyldopa, lowers blood pressure by inhibitingthe outflow of sympathetic vasoconstrictor impulses fromthe brain. Early studies had suggested that the hypotensiveaction of α-methyldopa was a result of the peripheral propertiesof the drug as a decarboxylase inhibitor or a falsetransmitter.
Clinical Use
Ethyl methyldopate hydrochloride is used as a step 2 agent and is recommendedfor patients with high blood pressure who are not responsiveto diuretic therapy alone. Ethyl methyldopate hydrochloride, suitable for oral use,is a zwitterion and is not soluble enough for parenteral use.The problem was solved by making the ester, leaving theamine free to form the water-soluble hydrochloride salt. It issupplied as a stable, buffered solution, protected with antioxidantsand chelating agents.
Safety information for Ethyl methyldopate hydrochloride
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