KIRENOL
Synonym(s):(1R)-1-[(2S,4aR,4bS,6S,8R,8aS)-6-hydroxy-8-(hydroxymethyl)-2,4b,8-trimethyl-4,4a,5,6,7,8a,9,10-octahydro-3H-phenanthren-2-yl]ethane-1,2-diol
- CAS NO.:52659-56-0
- Empirical Formula: C20H34O4
- Molecular Weight: 338.49
- MDL number: MFCD00210519
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-09-04 15:51:00
What is KIRENOL?
Description
Kirenol is a diterpenoid that has been found in S. orientalis and has diverse biological activities, including anti-arthritic and anti-inflammatory properties. It inhibits Gram-positive and Gram-negative bacterial growth in disc diffusion assays with MICs ranging from 39 to 156 and 312.5 to 625 μg/ml, respectively. Kirenol also reduces K652 chronic myeloid leukemia cell viability with a 48 hour IC50 value of 18.19 μg/ml and induces apoptosis. In vivo, kirenol (2 mg/kg, p.o.) reduces motor deficit, delays disease onset by approximately five days, and downregulates inflammatory CD4+IFN-γ+ Th1 cells and CD4+IL-17A+ Th17 cells in a mouse model of experimental autoimmune encephalomyelitis (EAE). Intragastric administration of kirenol (1-4 mg/kg) reduces the arthritis index, NF-kB activity, and paw swelling and increases annexin-1 expression without affecting glucocorticoid receptor α (GRα) expression in the synovium in a rat model of collagen-induced arthritis. Topical administration of kirenol (0.3-0.5% w/w) reduces edema induced by carrageenan, complete Freund''s adjuvant (CFA), and formalin in rats up to 44, 67, and 65%, respectively.
The Uses of KIRENOL
Kirenol is a pharmaceutical agent that induces apoptosis in human chronic myeloid leukemia cells.
Definition
ChEBI: Kirenol is a diterpenoid.
Properties of KIRENOL
Melting point: | 197.0 to 201.0 °C |
Boiling point: | 516.9±35.0 °C(Predicted) |
Density | 1.17±0.1 g/cm3(Predicted) |
storage temp. | -20°C Freezer |
solubility | Ethanol (Slightly), Methanol (Slightly) |
form | Solid |
pka | 14.06±0.20(Predicted) |
color | White to Light Yellow |
CAS DataBase Reference | 52659-56-0 |
Safety information for KIRENOL
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for KIRENOL
New Products
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