Julolidine
Synonym(s):2,3,6,7-Tetrahydro-1H,5H-benzo[ij]quinolizine
- CAS NO.:479-59-4
- Empirical Formula: C12H15N
- Molecular Weight: 173.25
- MDL number: MFCD00006917
- EINECS: 207-535-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-15 10:43:23
What is Julolidine?
Chemical properties
CLEAR YELLOW TO ORANGE-BROWN LIQUID AFTER MELTING
The Uses of Julolidine
Julolidine used as amine building block and in chemoluminescent dye. Also used in photoconductive materials, chemiluminescence substances, chromogenic substrates in analytical redox reactions, dye intermediates, potential antidepressants and tranquilizers, nonlinear optical materials, high sensitivity photopolymerizable materials, and for improving color stability in photography.
Purification Methods
Purify julolidine by dissolving it in dilute HCl, steam is bubbled through the solution and the residual acidic solution is basified with 10N NaOH, extracted with Et2O, washed with H2O, dried (NaOH pellets), filtered, evaporated and distilled in vacuo. The distillate crystallises on cooling (m 39-40o). It develops a red colour on standing in contact with air for several days. The colour can be removed by distilling or dissolving in 2-3 parts of hexane, adding charcoal, filtering and cooling in an Me2CO/Dry-ice bath when julolidine crystallises out (85-90% yield m 39-40o). The hydrobromide [83646-41-7] has m 218o (239-242o), the picrate has m 174o(165o) and the methiodide crystallises from MeOH, with m 186o [Glass & Weisberger Org Synth Coll Vol III 504 1955, Smith & Yu J Org Chem 17 1285 1952, Beilstein 20 H 332, 20 I 133, 20 II 214, 20 III/IV 3281.] Highly TOXIC.
Properties of Julolidine
Melting point: | 34-36 °C(lit.) |
Boiling point: | 170-173°C 31mm |
Density | 1.0030 |
refractive index | 1.5680 |
Flash point: | >230 °F |
storage temp. | 2-8°C |
solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
pka | 6.54±0.20(Predicted) |
form | Liquid After Melting |
color | Clear yellow to orange-brown |
Water Solubility | Soluble in toluene. Insoluble in water. |
Sensitive | Air Sensitive |
BRN | 139925 |
CAS DataBase Reference | 479-59-4(CAS DataBase Reference) |
NIST Chemistry Reference | Julolidine(479-59-4) |
EPA Substance Registry System | 1H,5H-Benzo[ij]quinolizine, 2,3,6,7-tetrahydro- (479-59-4) |
Safety information for Julolidine
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Julolidine
InChIKey | DZFWNZJKBJOGFQ-UHFFFAOYSA-N |
Abamectin manufacturer
Dr. Silviu Pharmachem Pvt., Ltd.
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