JTC 801
Synonym(s):N-(4-amino-2-methylquinolin-6-yl)-2-(4-ethylphenoxymethyl)benzamide hydrochloride
- CAS NO.：244218-51-7
- Empirical Formula: C26H25N3O2.ClH
- Molecular Weight: 447.963
- MDL number: MFCD06198707
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-30 15:45:59
What is JTC 801?
The Uses of JTC 801
JTC 801 is a novel opioid receptor-like1 (ORL1) receptor antagonist.
What are the applications of Application
JTC 801 is a high affinity, selective NOP (KOR-3) receptor antagonist
Biological Activity
High affinity, selective NOP receptor antagonist (K i = 8.2 nM). Displays approximately 12.5-, 129- and 1055-fold selectivity over human μ -, κ - and δ -opioid receptors respectively. In vivo shows anti-nociceptive effects in acute pain models. Orally active.
storage
Desiccate at RT
Properties of JTC 801
| Melting point: | 235℃ |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | DMSO: ≥20mg/mL |
| form | powder |
| color | tan |
Safety information for JTC 801
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for JTC 801
| InChIKey | NQLIYKXNAXKMBL-UHFFFAOYSA-N |
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