JC-1
Synonym(s):5,5′,6,6′-Tetrachloro-1,1′,3,3′-tetraethylbenzimidazolocarbocyanine iodide;5,5′,6,6′-Tetrachloro-1,1′,3,3′-tetraethyl-imidacarbocyanine iodide;CBIC2(3)
- CAS NO.:3520-43-2
- Empirical Formula: C25H27Cl4N4.I
- Molecular Weight: 652.228
- MDL number: MFCD00188475
- EINECS: 200-258-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-08 09:02:15
What is JC-1?
Description
JC-
The Uses of JC-1
A dual-emission potential-sensitive probe that can be used to measure mitochondrial membrane potential. JC-1 is a green-fluorescent monomer at low membrane potential. At higher potentials, JC-1 forms red-fluorescent "J-aggregates," which exhibit broad exc
The Uses of JC-1
The cyanine dye JC-1 has been used to determine mitochondrial transmembrane potential.
What are the applications of Application
JC-1 iodide is a mitochondrial membrane potential dye and fluorescent probe used to test Pgp activity.
Definition
ChEBI: 1,1',3,3'-tetraethyl-5,5',6,6'-tetrachloroimidacarbocyanine iodide is a cyanine dye and an organic iodide salt. It has a role as a fluorochrome. It contains a 1,1',3,3'-tetraethyl-5,5',6,6'-tetrachloroimidacarbocyanine.
References
1) Reers et al. (1991), J-aggregate formation of a carbocyanine as a quantitative fluorescent indicator of membrane potential; Biochemistry, 30 4480 2) Smiley et al. (1991), Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1; Proc. Natl. Acad. Sci. USA, 88 3671 3) Lisa et al. (1995), Mitochondrial membrane potential in single living adult rat cardiac myocytes exposed to anoxia or metabolic inhibition; J. Physiol., 486 1 4) Wolosin et al. (2017), Application of JC1 for non-toxic isolation of cells with MDR transporter activity by flow cytometry; PLoS One, 12(4) e0174905 5) Wang et al. (2017), A novel cytoprotective peptide protects mesenchymal stem cells against mitochondrial dysfunction and apoptosis induced by starvation via Nrf2/Sirt3/FoxO3a pathway; J. Transl. Med., 15 33
Properties of JC-1
Melting point: | 275–278 ℃ |
storage temp. | room temp |
solubility | Soluble in methanol, N,N-dimethyl formamide, dimethyl sulfoxide |
form | crystals |
color | Deep red |
λmax | 514nm |
Stability: | Store as supplied desiccated at -20°C for up to 2 years from the date of purchase. Solutions in DMSO or distilled water may be stored at 4°C for up to 1 year. DO NOT FREEZE/THAW SOLUTIONS. Sterilize solutions only by filtration, not by autoclaving |
Biological Applications | Detectingmitochondrialmembrane potential,ABCB1,ABCC1,and ABCG2 transporters inhibitors,nucleic acid hybridization,prostate cancer; treating cellular death,Alzheimer’s disease; apoptosis assay; cytotoxicity assay; hematotoxicity |
Major Application | Langmuir-Blodgett films;
lasing systems; nonlinear optical materials;
photographic materials1, |
Safety information for JC-1
Computed Descriptors for JC-1
InChIKey | FYNNIUVBDKICAX-UHFFFAOYSA-M |
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