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HomeProduct name listISOPROPYLSULFONYL CHLORIDE

ISOPROPYLSULFONYL CHLORIDE

  • CAS NO.:10147-37-2
  • Empirical Formula: C3H7ClO2S
  • Molecular Weight: 142.6
  • MDL number: MFCD00007453
  • EINECS: 233-415-2
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-05-15 10:43:27
ISOPROPYLSULFONYL CHLORIDE Structural

What is ISOPROPYLSULFONYL CHLORIDE?

Chemical properties

Clear pale yellow-greenish liquid

The Uses of ISOPROPYLSULFONYL CHLORIDE

2-Propanesulfonyl chloride (isopropylsulfonyl chloride) can be used as a reactant to prepare:

  • 1-Isopropylsulfonyl-2-amine benzimidazole by reacting with 2-aminobenzimidazole via N-sulfonylation reaction in the presence of a base.
  • Bis(isopropylsulfonyl)disulfide, a sulfurizing agent, used to synthesize phosphorothioate oligonucleotide analogs.

The Uses of ISOPROPYLSULFONYL CHLORIDE

2-Propanesulfonyl chloride is used as a pharmaceutical intermediate. Reductive cleavage of a secondary alcohol to methylene has been achieved by reduction of the 2-propanesulfonyl ester with lithium triethylborohydride.

What are the applications of Application

2-Propanesulfonyl chloride is a product for proteomics research

General Description

The solvolysis of 2-propanesulfonyl chloride by an addition-elimination (association-dissociation) pathway was studied.

Properties of ISOPROPYLSULFONYL CHLORIDE

Melting point: -47°C
Boiling point: 74-75 °C/19 mmHg (lit.)
Density  1.27 g/mL at 25 °C (lit.)
vapor density  4 (vs air)
vapor pressure  15.5 mm Hg ( 25 °C)
refractive index  n20/D 1.453(lit.)
Flash point: 187 °F
storage temp.  under inert gas (nitrogen or Argon) at 2-8°C
solubility  Acetontrile (Slightly), Chloroform (Slightly)
form  clear liquid
Specific Gravity 1.270
color  Colorless to Light yellow to Light orange
Water Solubility  Reacts with water.
Sensitive  Lachrymatory
BRN  1747497
CAS DataBase Reference 10147-37-2(CAS DataBase Reference)

Safety information for ISOPROPYLSULFONYL CHLORIDE

Signal word Danger
Pictogram(s)
ghs
Corrosion
Corrosives
GHS05
GHS Hazard Statements H314:Skin corrosion/irritation
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.
P363:Wash contaminated clothing before reuse.
P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405:Store locked up.

Computed Descriptors for ISOPROPYLSULFONYL CHLORIDE

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