ISOPROPYLSULFONYL CHLORIDE

CAS NO.：10147-37-2
Empirical Formula: C3H7ClO2S
Molecular Weight: 142.6
MDL number: MFCD00007453
EINECS: 233-415-2
SAFETY DATA SHEET (SDS)
Update Date: 2023-05-15 10:43:27

What is ISOPROPYLSULFONYL CHLORIDE?

Chemical properties

Clear pale yellow-greenish liquid

The Uses of ISOPROPYLSULFONYL CHLORIDE

2-Propanesulfonyl chloride (isopropylsulfonyl chloride) can be used as a reactant to prepare:

1-Isopropylsulfonyl-2-amine benzimidazole by reacting with 2-aminobenzimidazole via N-sulfonylation reaction in the presence of a base.
Bis(isopropylsulfonyl)disulfide, a sulfurizing agent, used to synthesize phosphorothioate oligonucleotide analogs.

The Uses of ISOPROPYLSULFONYL CHLORIDE

2-Propanesulfonyl chloride is used as a pharmaceutical intermediate. Reductive cleavage of a secondary alcohol to methylene has been achieved by reduction of the 2-propanesulfonyl ester with lithium triethylborohydride.

What are the applications of Application

2-Propanesulfonyl chloride is a product for proteomics research

General Description

The solvolysis of 2-propanesulfonyl chloride by an addition-elimination (association-dissociation) pathway was studied.

Properties of ISOPROPYLSULFONYL CHLORIDE

Melting point:	-47°C
Boiling point:	74-75 °C/19 mmHg (lit.)
Density	1.27 g/mL at 25 °C (lit.)
vapor density	4 (vs air)
vapor pressure	15.5 mm Hg ( 25 °C)
refractive index	n20/D 1.453(lit.)
Flash point:	187 °F
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	Acetontrile (Slightly), Chloroform (Slightly)
form	clear liquid
Specific Gravity	1.270
color	Colorless to Light yellow to Light orange
Water Solubility	Reacts with water.
Sensitive	Lachrymatory
BRN	1747497
CAS DataBase Reference	10147-37-2(CAS DataBase Reference)

Safety information for ISOPROPYLSULFONYL CHLORIDE

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05
GHS Hazard Statements	H314:Skin corrosion/irritation
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P363:Wash contaminated clothing before reuse. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.