ISOPROPYLSULFONYL CHLORIDE
- CAS NO.：10147-37-2
- Empirical Formula: C3H7ClO2S
- Molecular Weight: 142.6
- MDL number: MFCD00007453
- EINECS: 233-415-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-15 10:43:27
What is ISOPROPYLSULFONYL CHLORIDE?
Chemical properties
Clear pale yellow-greenish liquid
The Uses of ISOPROPYLSULFONYL CHLORIDE
2-Propanesulfonyl chloride (isopropylsulfonyl chloride) can be used as a reactant to prepare:
- 1-Isopropylsulfonyl-2-amine benzimidazole by reacting with 2-aminobenzimidazole via N-sulfonylation reaction in the presence of a base.
- Bis(isopropylsulfonyl)disulfide, a sulfurizing agent, used to synthesize phosphorothioate oligonucleotide analogs.
The Uses of ISOPROPYLSULFONYL CHLORIDE
2-Propanesulfonyl chloride is used as a pharmaceutical intermediate. Reductive cleavage of a secondary alcohol to methylene has been achieved by reduction of the 2-propanesulfonyl ester with lithium triethylborohydride.
What are the applications of Application
2-Propanesulfonyl chloride is a product for proteomics research
General Description
The solvolysis of 2-propanesulfonyl chloride by an addition-elimination (association-dissociation) pathway was studied.
Properties of ISOPROPYLSULFONYL CHLORIDE
| Melting point: | -47°C |
| Boiling point: | 74-75 °C/19 mmHg (lit.) |
| Density | 1.27 g/mL at 25 °C (lit.) |
| vapor density | 4 (vs air) |
| vapor pressure | 15.5 mm Hg ( 25 °C) |
| refractive index | n |
| Flash point: | 187 °F |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | Acetontrile (Slightly), Chloroform (Slightly) |
| form | clear liquid |
| Specific Gravity | 1.270 |
| color | Colorless to Light yellow to Light orange |
| Water Solubility | Reacts with water. |
| Sensitive | Lachrymatory |
| BRN | 1747497 |
| CAS DataBase Reference | 10147-37-2(CAS DataBase Reference) |
Safety information for ISOPROPYLSULFONYL CHLORIDE
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05 |
| GHS Hazard Statements |
H314:Skin corrosion/irritation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P363:Wash contaminated clothing before reuse. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for ISOPROPYLSULFONYL CHLORIDE
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