2-Propanethiol

Synonym(s):1-Methylethanethiol;2-Propanethiol;Isopropyl mercaptan

CAS NO.：75-33-2
Empirical Formula: C3H8S
Molecular Weight: 76.16
MDL number: MFCD00004863
EINECS: 200-861-4
SAFETY DATA SHEET (SDS)
Update Date: 2024-08-21 22:41:43

What is 2-Propanethiol?

Chemical properties

liquid with an exceedingly unpleasant smell

Occurrence

2-Propanethiol is a volatile sulfur compound that is reported to occur in irradiated beef.

The Uses of 2-Propanethiol

2-Propanethiol is used in preparation of polyol block copolymer. It is also used as standard for petroleum analysis; as intermediate; as natural gas odorant.

Definition

ChEBI: 2-Propanethiol is an alkanethiol that is propane substituted by a sulfanyl group at position 2.

Preparation

2-Propanethiol is synthesised by the reaction of sodium hydrosulfide and brominated isopropane.

General Description

Isopropyl mercaptan is a white liquid with a strong skunk-like odor. (USCG, 1999)

Air & Water Reactions

Highly flammable. Soluble in water.

Reactivity Profile

2-Propanethiol is incompatible with acids, diazo and azo compounds, halocarbons, isocyanates, aldehydes, alkali metals, nitrides, hydrides, and other strong reducing agents. Reactions with these materials generate heat and in many cases hydrogen gas. May liberate hydrogen sulfide when mixed with an acid.

Hazard

Highly flammable, dangerous fire hazard.

Health Hazard

Inhalation causes loss of sense of smell, muscular weakness, convulsions, respiratory paralysis. Ingestion causes nausea and vomiting. Contact with eyes or skin causes irritation.

Purification Methods

Purify it as for propane-1-thiol above. [Beilstein 1 IV 1498.]

Properties of 2-Propanethiol

Melting point:	−131 °C(lit.)
Boiling point:	57-60 °C(lit.)
Density	0.82 g/mL at 25 °C(lit.)
vapor density	2.6 (vs air)
vapor pressure	455 mm Hg ( 37.8 °C)
refractive index	n20/D 1.426(lit.)
FEMA	3897 \| 2-PROPANETHIOL
Flash point:	<−30 °F
storage temp.	Store below +30°C.
form	Liquid
pka	pK1:10.86 (25°C,μ=0.1)
color	Colorless
Odor	Powerful skunk.
Odor Threshold	0.000006ppm
Water Solubility	Slightly soluble in water
Sensitive	Air Sensitive
JECFA Number	510
BRN	605260
Stability:	Stable. Highly flammable - note low flashpoint. May form explosive mixtures with air.
CAS DataBase Reference	75-33-2(CAS DataBase Reference)
NIST Chemistry Reference	2-Propanethiol(75-33-2)
EPA Substance Registry System	Isopropyl mercaptan (75-33-2)

Safety information for 2-Propanethiol

Signal word	Danger
Pictogram(s)	Flame Flammables GHS02 Exclamation Mark Irritant GHS07 Environment GHS09
GHS Hazard Statements	H225:Flammable liquids H317:Sensitisation, Skin H410:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P233:Keep container tightly closed. P240:Ground/bond container and receiving equipment. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.