Iron saccharate
- CAS NO.:8047-67-4
- Empirical Formula: C18H24Fe2O24
- Molecular Weight: 736.06
- MDL number: MFCD29050328
- EINECS: 232-464-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-01 18:09:03
What is Iron saccharate?
Absorption
The intravensously administered iron sucrose injection would result rapidly in high serum iron levels. Maximum measured levels occured after 10 min of injection with an average of 30.00 mg/l.
Toxicity
Hypersensitivity reactions, including anaphylactic shock, loss of consciousness, collapse, hypotension, dyspnea, and seizure. Monitor iron toxicity through the periodic evaluation of lab works which monitor the body concentration of iron. Lab monitoring of the following parameters: transferrin saturation, serum ferritin concentrations, hemoglobin, and hematocrit could be helpful to avoid iron overload. Severe allergic symptoms include: rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); burning or pain at the injection site; burning, numbness, or tingling; chest pain; fainting; loss of consciousness; severe or persistent dizziness, headache, or light-headedness; seizures; shortness of breath; swelling of the hands, ankles, or feet.
Chemical properties
Brown solid
The Uses of Iron saccharate
Semi-synthetic macrolide antibiotic
The Uses of Iron saccharate
Iron Saccharate has been used to treat iron deficiency and iron deficiency anemia associated with different chronic diseases.
Background
Iron sucrose (sucroferric oxyhydroxide or iron saccharate) is used as a source of iron in patients with iron deficiency anemia with chronic kidney disease (CKD), including those who are undergoing dialysis (hemodialysis or peritoneal) and those who do not require dialysis. Due to less side effects than iron dextran, iron sucrose is more preferred in chronic kidney disease patients.
Indications
Iron sucrose is elemental iron as an injection. It replenishes body iron stores in patients with iron deficiency.
brand name
Venofer (Luitpold).
Pharmacokinetics
Significant increases in serum iron and serum ferritin and significant decreases in total iron binding capacity occurred four weeks from the initiation of iron sucrose treatment.
Clinical Use
Phosphate binder
Metabolism
Following IV administration, dissociated into iron and sucrose by the reticuloendothelial system.
Properties of Iron saccharate
Melting point: | 168-171°C |
storage temp. | Refrigerator |
solubility | Water (Slightly) |
form | Solid |
color | Brown to Dark Brown |
InChI | InChI=1/3C6H10O8.2Fe/c3*7-1(3(9)5(11)12)2(8)4(10)6(13)14;;/h3*1-4,7-10H,(H,11,12)(H,13,14);;/q;;;2*+3/p-6/t3*1-,2-,3-,4+;;/s3 |
CAS DataBase Reference | 8047-67-4(CAS DataBase Reference) |
IARC | 3 (Vol. 2, Sup 7) 1987 |
EPA Substance Registry System | Iron saccharate (8047-67-4) |
Safety information for Iron saccharate
Computed Descriptors for Iron saccharate
InChIKey | ADQSUDSYBZBMFT-JMMWHMDLNA-H |
Abamectin manufacturer
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