iopronic acid
- CAS NO.:37723-78-7
- Empirical Formula: C15H18I3NO5
- Molecular Weight: 673.02
- EINECS: 253-643-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 17:34:38
What is iopronic acid?
Originator
Bilimiru,Bracco,Italy,1974
The Uses of iopronic acid
Diagnostic aid (radiopaque medium, cholecystographic).
Definition
ChEBI: Iopronic acid is an aromatic amide.
Manufacturing Process
,A solution of 192 g 3-acetylamino-2,4,6-triiodophenol, sodium (0.35 mol) in
350 ml dimethylacetamide, was mixed with 107.5 g 3-(2-iodoethoxy)-2-
ethylpropionic acid ethyl ester (0.35 mol) at 90°C with stirring over a period
of about 20 to 30 minutes. Stirring was continued while the mixture was held
at 95°C to 100°C for 16 hours. The solvent was then removed by distillation
in a vacuum, and the residue was poured into 4,000 ml water. The solid
precipitate formed was recovered and washed with water, dilute sodium
carbonate solution, dilute sodium bisulfite solution, and again with much
water. The ethyl ester was obtained in a yield of 220 g (90%). When
recrystallized from 75% aqueous ethanol, it melted at 80°C to 86°C.
The ester (70 g, 0.1 mol) was saponified in a boiling mixture of 250 ml
methanol and 250 ml water to which 100 ml N sodium hydroxide solution was
added in small batches with stirring. The methanol was distilled from the
saponification mixture, the residue was mixed with water and extracted with
ethyl acetate. The aqueous phase was acidified with hydrochloric acid in the
presence of sodium bisulfite.
The free acid gradually crystallized from the acidified solution in the amount of42.4 g (63% yield). When recrystallized from 50% ethanol and from ethyl
acetate, it melted at 130°C.
brand name
Bilimiro (Bracco Industria Chimica S.p.A., Italy); Bilimiron (Bracco Industria Chimica S.p.A., Italy); Oravue (Bristol-Myers Squibb); Videobil (Bracco Industria Chimica S.p.A., Italy).
Therapeutic Function
Diagnostic aid (radiopaque medium)
Properties of iopronic acid
Melting point: | 130°C |
Boiling point: | 674.2±55.0 °C(Predicted) |
Density | 2.0615 (estimate) |
pka | 4.28±0.10(Predicted) |
Water Solubility | 20.08g/L(37 ºC) |
Safety information for iopronic acid
Computed Descriptors for iopronic acid
New Products
4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Diclofenac Sodium IP/BP/EP/USP Mefenamic Acid IP/BP/EP/USP Ornidazole IP Diclofenac Potassium THOMAIND PAPER PH 2.0 TO 4.5 1 BOX BUFFER CAPSULE PH 9.2 - 10 CAP SODIUM CHLORIDE 0.1N CVS ALLOXAN MONOHYDRATE 98% PLATINUM 0.5% ON 3 MM ALUMINA PELLETS (TYPE 73) LITHIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
You may like
-
1-Methyl-6-oxo-1,6-dihydropyridazine-3-carbonitrile 98%View Details
99903-60-3 -
88491-46-7 98%View Details
88491-46-7 -
1823368-42-8 98%View Details
1823368-42-8 -
2-(3-(tert-butyl)phenoxy)-2-methylpropanoic acid 1307449-08-6 98%View Details
1307449-08-6 -
Ethyl 3-(furan-2-yl)-3-hydroxypropanoate 25408-95-1 98%View Details
25408-95-1 -
2-Chloro-5-fluoro-1-methoxy-3-methylbenzene 98%View Details
1805639-70-6 -
1784294-80-9 98%View Details
1784294-80-9 -
Lithium ClavulanateView Details
61177-44-4