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inulicin

inulicin Structural

What is inulicin?

Biological Activity

Inulicin (1-O-Acetylbritannilactone) is an active compound isolated from Inula Britannica L. It inhibits VEGF-mediated activation of Src and FAK. It also inhibits LPS-induced PGE2 production and COX-2 expression, as well as NF-κB activation and translocation.

in vivo

Administration of a single dose of Inulicin (1-O-Acetylbritannilactone; 12 mg/kg/day) remarkably suppresses growth of A549 xenografts in nude mice. In vivo microvessels formation and Src activation are also significantly inhibited in Inulicin-treated xenograft tumors. To investigate the potential activity of Inulicin in vivo, a nude mice xenograft model is applied.

Properties of inulicin

Melting point: 124.0-126.1 °C
Boiling point: 481.7±45.0 °C(Predicted)
Density  1.16
storage temp.  4°C, protect from light
solubility  DMSO: soluble
form  A solid
pka 13.71±0.60(Predicted)
color  White to off-white

Safety information for inulicin

Computed Descriptors for inulicin

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