Indisulam

Synonym(s):N-(3-chloro-1H-indol-7-yl)-4-sulfamoylbenzenesulfonamide;N₁-(3-Chloro-1H-indol-7-yl)-1,4-benzenedisulfonamide

CAS NO.：165668-41-7
Empirical Formula: C14H12ClN3O4S2
Molecular Weight: 385.85
MDL number: MFCD00945325
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-06 15:28:16

What is Indisulam?

Definition

ChEBI: Indisulam is a chloroindole that is 3-chloro-1H-indole substituted by a [(4-sulfamoylphenyl)sulfonyl]nitrilo group at position 7. It is a carbonic anhydrase inhibitor and a potential anti-cancer agent currently in clinical development. It has a role as an EC 4.2.1.1 (carbonic anhydrase) inhibitor and an antineoplastic agent. It is a chloroindole, a sulfonamide and an organochlorine compound.

Biochem/physiol Actions

Indisulam is a carbonic anhydrase inibitor and Antitumor CDK inhibitor. Indisulam targets the G1 phase of the cell cycle by depleting cyclin E. inducing p53 and p21, and inhibiting CDK2, causing a blockade in the G1/S transition.

storage

Store at -20°C

Properties of Indisulam

Melting point:	242-243 °C (decomp)(Solv: ethanol (64-17-5); water (7732-18-5))
Boiling point:	668.9±65.0 °C(Predicted)
Density	1.663±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	DMSO : 100 mg/mL (259.17 mM; Need ultrasonic)
pka	8.14±0.30(Predicted)
form	powder
color	white to beige

Safety information for Indisulam

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention.