Indisulam
Synonym(s):N-(3-chloro-1H-indol-7-yl)-4-sulfamoylbenzenesulfonamide;N1-(3-Chloro-1H-indol-7-yl)-1,4-benzenedisulfonamide
- CAS NO.：165668-41-7
- Empirical Formula: C14H12ClN3O4S2
- Molecular Weight: 385.85
- MDL number: MFCD00945325
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-17 16:00:36
What is Indisulam?
Definition
ChEBI: Indisulam is a chloroindole that is 3-chloro-1H-indole substituted by a [(4-sulfamoylphenyl)sulfonyl]nitrilo group at position 7. It is a carbonic anhydrase inhibitor and a potential anti-cancer agent currently in clinical development. It has a role as an EC 4.2.1.1 (carbonic anhydrase) inhibitor and an antineoplastic agent. It is a chloroindole, a sulfonamide and an organochlorine compound.
Biochem/physiol Actions
Indisulam is a carbonic anhydrase inibitor and Antitumor CDK inhibitor. Indisulam targets the G1 phase of the cell cycle by depleting cyclin E. inducing p53 and p21, and inhibiting CDK2, causing a blockade in the G1/S transition.
storage
Store at -20°C
Properties of Indisulam
| Melting point: | 242-243 °C (decomp)(Solv: ethanol (64-17-5); water (7732-18-5)) |
| Boiling point: | 668.9±65.0 °C(Predicted) |
| Density | 1.663±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO : 100 mg/mL (259.17 mM; Need ultrasonic) |
| pka | 8.14±0.30(Predicted) |
| form | powder |
| color | white to beige |
Safety information for Indisulam
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for Indisulam
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