Imipenem-Cilastatin sodium hydrate
- CAS NO.:92309-29-0
- Empirical Formula: C28H43N5O9S2
- Molecular Weight: 657.8
- EINECS: 1592732-453-0
- SAFETY DATA SHEET (SDS)
What is Imipenem-Cilastatin sodium hydrate?
Clinical Use
Antibacterial agent
Drug interactions
Potentially hazardous interactions with other drugs
Antiepileptics: reduced valproate concentration -
avoid.
Antivirals: convulsions reported with concomitant
administration of ganciclovir and valganciclovir.
Ciclosporin: variable reports of increase / no change
in ciclosporin levels, and of neurotoxicity.
Metabolism
When administered alone, imipenem is metabolised in the kidneys by dehydropeptidase-I, an enzyme in the brush border of the renal tubules, to inactive, nephrotoxic metabolites, with only about 5 to 40 or 45% of a dose excreted in the urine as unchanged active drug. Cilastin inhibits the metabolism of imipenem. When given with cilastatin about 70% of an intravenous dose of imipenem is recovered unchanged in the urine within 10 hours. Cilastatin is also excreted mainly in the urine, the majority as unchanged drug and about 12% as N-acetyl cilastatin. Less than 1% of imipenem is excreted via the bile in the faeces.
Safety information for Imipenem-Cilastatin sodium hydrate
Abamectin manufacturer
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