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HomeProduct name listILIMAQUINONE

ILIMAQUINONE

Synonym(s):3-[(Decahydro-1β,2β,4aβ-trimethyl-5-methylene-1-napthyl)methyl]-2-hydroxy-5-methoxybenzoquinone, IQ;Ilimaquinone - CAS 71678-03-0 - Calbiochem

ILIMAQUINONE Structural

What is ILIMAQUINONE?

Description

Ilimaquinone is a natural sesquiterpene quinone that has antimicrobial, anti-HIV, anti-mitotic, and anti-inflammatory properties. In mammalian cells, 25 μM ilimaquinone reversibly induces vesiculation of Golgi membranes, blocking the secretory pathway. It inhibits the conversion of S-adenosylhomocysteine (SAH) to homocysteine by SAH hydrolase (IC50 = 40 μM). Ilimaquinone also inhibits DNA polymerase β and dual specificity phosphatase Cdc25B (IC50 = 45.2 and 92 μM, respectively) and, at 10 μM, activates gene expression through hypoxia-inducible factor-1.

The Uses of ILIMAQUINONE

Ilimaquinone is an ADP-ribosylation factor (ARF) and β-COP to the Golgi membrane inhibitor.

The Uses of ILIMAQUINONE

Biological probe for intracellular communications and vesicle-mediated transport.

What are the applications of Application

Ilimaquinone is an ADP-ribosylation factor (ARF) and β-COP to the Golgi membrane inhibitor

Definition

ChEBI: A natural product found in Dactylospongia elegans.

General Description

A cell-permeable marine sponge metabolite with anti-microbial, anti-HIV, anti-inflammatory, and anti-mitotic properties. Induces a complete and reversible breakdown of Golgi membranes into smaller vesicular structures and causes depolymerization of microtubules. Inhibits cellular methylations through its interaction with S-adenosylhomocysteinase. Blocks the cytotoxicity of ricin and diphtheria toxin. Acts as an inhibitor of the RNase H activity of HIV-1.

Biochem/physiol Actions

Primary TargetInduces a complete and reversible breakdown of Golgi membranes into smaller vesicular structures and causes depolymerization of microtubules.

Properties of ILIMAQUINONE

Melting point: 108-110℃ (pentane )
Boiling point: 478.4±45.0 °C(Predicted)
alpha  D23 -23.2° (c = 1.12 in CHCl3)
Density  1.14±0.1 g/cm3(Predicted)
storage temp.  −20°C
solubility  DMSO: Soluble; Ethanol: Soluble; Hexane: Soluble; Methanol: Soluble
pka 2.92±0.50(Predicted)
form  Red solid
color  Light yellow to brown

Safety information for ILIMAQUINONE

Computed Descriptors for ILIMAQUINONE

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