5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM
Synonym(s):β:γ-Imidoguanosine 5′-triphosphate trisodium salt hydrate;5′-Guanylyl-imidodiphosphate trisodium salt hydrate;GMP-PNP;Gpp(NH)p
- CAS NO.:148892-91-5
- Empirical Formula: C10H18N6NaO13P3
- Molecular Weight: 546.19
- MDL number: MFCD00084770
- Update Date: 2023-04-23 13:52:06
What is 5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM?
The Uses of 5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM
Non-hydrolyzable analog of GTP; the preferred GTP analog to activate ADP-ribosylation factor.
The Uses of 5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM
Guanosine 5′-[β,γ-imido]triphosphate trisodium salt hydrate has been used: to study K-RAS interactions with the membrane, for the crystallization of Mycobacterium tuberculosis FtsZ, as a translation initiation inhibitor for the analysis of the 48S pre-initiation complex.
What are the applications of Application
Guanylyl Imidodiphosphate is a non-hydrolyzable GTP analog ARF (ADP-ribosylation factor) activator.
General Description
Guanosine 5′-[β,γ-imido]triphosphate (GMP-PNP, Gpp(NH)p) is a non-hydrolyzable analog of GTP that binds and irreversibly activates G proteins. Gpp(NH)p is used in a variety of applications that involve GTP binding, including GTP-activation, GTP-inhibition, GTP transport, GTP hydrolysis, and GTP structure stabilization. Since a cycle of GTP binding, hydrolysis, and release is required for the initiation of protein translocation across the endoplasmic reticulum, guanosine 5′-[β,γ-imido]triphosphate is often used in studies of protein synthesis. Gpp(NH)p is used to activate ADP-ribosylation factors and to modulate G proteins involved in cell signaling, protein synthesis and other metabolic processes.
Biochem/physiol Actions
Guanosine 5′-[?,γ-imido]triphosphate binds and irreversibly activates G proteins. Since a cycle of GTP binding, hydrolysis, and release is required for the initiation of protein translocation across the endoplasmic reticulum, this non-hydrolyzable GTP analog is often used in studies of protein synthesis.
Properties of 5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM
storage temp. | -70°C |
solubility | H2O: 50 mg/mL |
form | powder |
color | white |
Safety information for 5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM
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