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HomeProduct name list5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM

5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM

Synonym(s):β:γ-Imidoguanosine 5′-triphosphate trisodium salt hydrate;5′-Guanylyl-imidodiphosphate trisodium salt hydrate;GMP-PNP;Gpp(NH)p

  • CAS NO.:148892-91-5
  • Empirical Formula: C10H18N6NaO13P3
  • Molecular Weight: 546.19
  • MDL number: MFCD00084770
  • Update Date: 2023-04-23 13:52:06
5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM Structural

What is 5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM?

The Uses of 5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM

Non-hydrolyzable analog of GTP; the preferred GTP analog to activate ADP-ribosylation factor.

The Uses of 5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM

Guanosine 5′-[β,γ-imido]triphosphate trisodium salt hydrate has been used: to study K-RAS interactions with the membrane, for the crystallization of Mycobacterium tuberculosis FtsZ, as a translation initiation inhibitor for the analysis of the 48S pre-initiation complex.

What are the applications of Application

Guanylyl Imidodiphosphate is a non-hydrolyzable GTP analog ARF (ADP-ribosylation factor) activator.

General Description

Guanosine 5′-[β,γ-imido]triphosphate (GMP-PNP, Gpp(NH)p) is a non-hydrolyzable analog of GTP that binds and irreversibly activates G proteins. Gpp(NH)p is used in a variety of applications that involve GTP binding, including GTP-activation, GTP-inhibition, GTP transport, GTP hydrolysis, and GTP structure stabilization. Since a cycle of GTP binding, hydrolysis, and release is required for the initiation of protein translocation across the endoplasmic reticulum, guanosine 5′-[β,γ-imido]triphosphate is often used in studies of protein synthesis. Gpp(NH)p is used to activate ADP-ribosylation factors and to modulate G proteins involved in cell signaling, protein synthesis and other metabolic processes.

Biochem/physiol Actions

Guanosine 5′-[?,γ-imido]triphosphate binds and irreversibly activates G proteins. Since a cycle of GTP binding, hydrolysis, and release is required for the initiation of protein translocation across the endoplasmic reticulum, this non-hydrolyzable GTP analog is often used in studies of protein synthesis.

Properties of 5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM

storage temp.  -70°C
solubility  H2O: 50 mg/mL
form  powder
color  white

Safety information for 5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM

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