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HomeProduct name listHydroxyzine dihydrochloride

Hydroxyzine dihydrochloride

Synonym(s):Hydroxyzine dihydrochloride

  • CAS NO.:2192-20-3
  • Empirical Formula: C21H29Cl3N2O2
  • Molecular Weight: 447.83
  • MDL number: MFCD00058200
  • EINECS: 218-586-3
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-06-06 17:21:03
Hydroxyzine dihydrochloride Structural

What is Hydroxyzine dihydrochloride?

Chemical properties

White Solid

Originator

Atarax,UCB,France,1956

The Uses of Hydroxyzine dihydrochloride

Hydroxyzine dihydrochloride has been used in the study of comparative anxiolytic activity of various drugs in experimental models of rats.

The Uses of Hydroxyzine dihydrochloride

H1 receptor antagonist. Anxiolytic. Antihistaminic.

The Uses of Hydroxyzine dihydrochloride

Antihistaminic;H1 antogonist

The Uses of Hydroxyzine dihydrochloride

Anti histamines

What are the applications of Application

Hydroxyzine Dihydrochloride is a hetercyclic H1 receptor antagonist

Manufacturing Process

A mixture of 0.1 mol of N-mono-1-p-chlorobenzohydrylpiperazine and 0.1 mol of 1-chloro-2-(2-hydroxy-ethoxy)-ethane is heated for 3 hours to 150°C. The mass is then taken up in 100 ml of benzene and 100 ml of a 10% aqueous solution of NaOH; decanting takes place, and the benzene solution is washed with water and the solvent is evaporated. Vacuum distilling of the residue yields 1-p-chlorobenzohydryl-4-[2-(2-hydroxy-ethoxy)-ethyl]-piperazine, BP 220°C/0.5 mm Hg.
The corresponding dihydrochloride is prepared by dissolving this base in about twice its weight of alcohol, by treating it with excess of gaseous HCl and by precipitating it with ether. The solvent is decanted and the residue, dissolved in a minimum of alcohol, crystallizes on the addition of ether, MP 193°C.

brand name

Amplimexon (Amplimed).

Therapeutic Function

Tranquilizer

General Description

Hydroxyzine dihydrochloride is an antihistaminic drug and a member of the diphenylmethanes family. It exerts its action by blocking the action of histamine, a substance in the body that causes allergic symptoms.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Biochem/physiol Actions

Hydroxyzine dihydrochloride (HDH) is used to regulate anxiety. It is also used to treat bronchial asthma and to relax patients before surgery.

Properties of Hydroxyzine dihydrochloride

Melting point: 190-192°C
Flash point: 9℃
storage temp.  2-8°C
solubility  H2O: soluble
form  powder
color  White to Off-White
CAS DataBase Reference 2192-20-3(CAS DataBase Reference)
EPA Substance Registry System Ethanol, 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-, dihydrochloride (2192-20-3)

Safety information for Hydroxyzine dihydrochloride

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
ghs
Health Hazard
GHS08
GHS Hazard Statements H302:Acute toxicity,oral
H336:Specific target organ toxicity,single exposure; Narcotic effects
Precautionary Statement Codes P202:Do not handle until all safety precautions have been read and understood.
P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P308+P313:IF exposed or concerned: Get medical advice/attention.

Computed Descriptors for Hydroxyzine dihydrochloride

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