Hydroxyzine dihydrochloride
Synonym(s):Hydroxyzine dihydrochloride
- CAS NO.:2192-20-3
- Empirical Formula: C21H29Cl3N2O2
- Molecular Weight: 447.83
- MDL number: MFCD00058200
- EINECS: 218-586-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-06 17:21:03
What is Hydroxyzine dihydrochloride?
Chemical properties
White Solid
Originator
Atarax,UCB,France,1956
The Uses of Hydroxyzine dihydrochloride
Hydroxyzine dihydrochloride has been used in the study of comparative anxiolytic activity of various drugs in experimental models of rats.
The Uses of Hydroxyzine dihydrochloride
H1 receptor antagonist. Anxiolytic. Antihistaminic.
The Uses of Hydroxyzine dihydrochloride
Antihistaminic;H1 antogonist
The Uses of Hydroxyzine dihydrochloride
Anti histamines
What are the applications of Application
Hydroxyzine Dihydrochloride is a hetercyclic H1 receptor antagonist
Manufacturing Process
A mixture of 0.1 mol of N-mono-1-p-chlorobenzohydrylpiperazine and 0.1 mol
of 1-chloro-2-(2-hydroxy-ethoxy)-ethane is heated for 3 hours to 150°C. The
mass is then taken up in 100 ml of benzene and 100 ml of a 10% aqueous
solution of NaOH; decanting takes place, and the benzene solution is washed
with water and the solvent is evaporated. Vacuum distilling of the residue
yields 1-p-chlorobenzohydryl-4-[2-(2-hydroxy-ethoxy)-ethyl]-piperazine, BP
220°C/0.5 mm Hg.
The corresponding dihydrochloride is prepared by dissolving this base in about
twice its weight of alcohol, by treating it with excess of gaseous HCl and by
precipitating it with ether. The solvent is decanted and the residue, dissolved
in a minimum of alcohol, crystallizes on the addition of ether, MP 193°C.
brand name
Amplimexon (Amplimed).
Therapeutic Function
Tranquilizer
General Description
Hydroxyzine dihydrochloride is an antihistaminic drug and a member of the diphenylmethanes family. It exerts its action by blocking the action of histamine, a substance in the body that causes allergic symptoms.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Biochem/physiol Actions
Hydroxyzine dihydrochloride (HDH) is used to regulate anxiety. It is also used to treat bronchial asthma and to relax patients before surgery.
Properties of Hydroxyzine dihydrochloride
Melting point: | 190-192°C |
Flash point: | 9℃ |
storage temp. | 2-8°C |
solubility | H2O: soluble |
form | powder |
color | White to Off-White |
CAS DataBase Reference | 2192-20-3(CAS DataBase Reference) |
EPA Substance Registry System | Ethanol, 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-, dihydrochloride (2192-20-3) |
Safety information for Hydroxyzine dihydrochloride
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 Health Hazard GHS08 |
GHS Hazard Statements |
H302:Acute toxicity,oral H336:Specific target organ toxicity,single exposure; Narcotic effects |
Precautionary Statement Codes |
P202:Do not handle until all safety precautions have been read and understood. P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P308+P313:IF exposed or concerned: Get medical advice/attention. |
Computed Descriptors for Hydroxyzine dihydrochloride
Abamectin manufacturer
Calyx Chemicals and Pharmaceuticals Ltd
Symed Laboratories Ltd
Pharma Links
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