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HomeProduct name listHYDROXYLAMINE

HYDROXYLAMINE

Synonym(s):HDA

  • CAS NO.:7803-49-8
  • Empirical Formula: H3NO
  • Molecular Weight: 33.03
  • MDL number: MFCD00044522
  • EINECS: 232-259-2
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-07-11 08:40:50
HYDROXYLAMINE Structural

What is HYDROXYLAMINE?

Description

Hydroxylamine was first synthesized by Wilhem Clemens Lossen in 1865 in the laboratory of Wilhelm Heinrich Heintz while working in Halle. The Lossen synthesis originally generated hydroxylamine in aqueous solution. Anhydrous hydroxylamine was prepared later by Lobry de Bruyn and Crismer in 1891. The free base is extremely volatile, and industrial-scale production has been fraught with problems, including large explosions at facilities in the United States and Japan. Much of the hydroxylamine produced and transported is in salt form or as a dilute aqueous solution.

Chemical properties

slightly yellow liquid

Physical properties

White crystalline solid; orthogonal plates or needles; unstable; density 1.21g/cm3at 20°C; melts at 33°C; vaporizes at 58°C; very soluble in water, liquidammonia and lower alcohols; sparingly soluble in most other organic solvents;decomposes in hot water; pKa5.94 at 25°C.

The Uses of HYDROXYLAMINE

Hydroxylamine is used as a reducing agent in photography, in synthetic and analytical chemistry, as an antioxidant for fatty acids and soaps, and as a dehairing agent for hides. In addition, hydroxylamine is used in the production of cyclohexanone oxime, an isomer of caprolactam, which is an intermediate in the production of nylon-6. In the semiconductor industry, hydroxylamine can be a component of a solution that dissolves a photoresist following lithography. Hydroxylamine can also be used to selectively cleave asparaginyl-glycine peptide bonds.

The Uses of HYDROXYLAMINE

Reducing agent, organic synthesis.

The Uses of HYDROXYLAMINE

Reducing agent used in photographic processing, leather tanning, manufacturing of nylon and other polymers; as a stabilizer for natural rubber; to prevent the development of objectionable tastes and odors during the refining of fatty materials.

What are the applications of Application

Hydroxylamine solution is an inorganic compound used in organic synthesis and as a reducing agent

Definition

ChEBI: The simplest hydroxylamine, consisting of ammonia bearing a hydroxy substituent. It is an intermediate in the biological nitrification by microbes like bacteria.

Definition

hydroxylamine: A colourless solid,NH2OH, m.p. 33°C. It explodes onheating and may be employed as anoxidizing agent or reducing agent. Itis made by the reduction of nitratesor nitrites, and is used in makingnylon. With aldehydes and ketones itforms oximes.

Preparation

Hydroxylamine is unstable as a free base. It is prepared from hydroxy-lamine hydrochloride, NH2OH?HCl, which is obtained by electrolytic reduc-tion of ammonium chloride solution. The hydrochloride undergoes alkalinedecomposition to hydroxylamine, which is collected by vacuum distillation.

General Description

Odorless white crystalline solid. Sinks and mixes with water.

Air & Water Reactions

Decomposes rapidly at room temperature or when dissolved in hot water by internal oxidation-reduction. Reacts with water or steam to produce heat and corrosive liquids.

Reactivity Profile

HYDROXYLAMINE is a white solid, thermally unstable, decomposes rapidly at room temperature or when dissolved in hot water by internal oxidation-reduction. HYDROXYLAMINE should be stored below 10° C [Bailar, 1973, vol. 2, p. 272]. Explosive reaction with strong oxidizers (chromium trioxide, potassium dichromate) or powdered zinc upon heat. Reaction with zinc or calcium produces explosive bishydroxylamides. HYDROXYLAMINE ignites on contact with cupric sulfate, alkali metals (sodium, potassium), oxidants (e.g., barium oxide, barium peroxide, lead dioxide, potassium permanganate, chlorine), phosphorus trichloride and pentachloride. HYDROXYLAMINE reacts vigorously with hypochlorites, pyridine, carbonyls [Sax, 9th ed., 1996, p. 1875]. On contact with organic materials in thin layer (e.g., crystals on filter paper), HYDROXYLAMINE may ignite spontaneously in air. HYDROXYLAMINE explodes when heated above 70° C [Brauer, 1963, vol. 1, p. 502]. During a distillation process, an explosion occurred. Potassium hydroxide is thought to be involved in the explosion. Employees in the plant complained of chest pains and suffered chemical burns. Five people were killed by the explosion.

Hazard

Decomposes rapidly at room temperature, violently when heated, detonates in flame-heated test tube. Irritant to tissue.

Health Hazard

INHALATION: Moderately toxic by inhalation and oral routes with the following symptoms possible: headache, vertigo, tinnitus, dyspnea, nausea and vomiting, cyanosis, proteinuria and hematuria, jaundice, restlessness, and convulsion. Methemoglobinemia has been reported. EYES: Corrosive - highly irritating. SKIN: Irritating or corrosive to skin. INGESTION: Moderately toxic by inhalation and oral routes with the following symptoms possible; headache, vertigo, tinnitus, dyspnea, nausea and vomiting, cyanosis, proteinuria and hematuria, jaundice, restlessness, and convulsion. Methemoglobinemia has been reported.

Contact allergens

Hydroxylamine and its salts are used in various branches of industry, as reducing agents in color film developers or as reagents in laboratories.

Potential Exposure

Potential Exposure:Mutagen.Those involved in chemical synthesis or use of hydroxyI-amine. Used as a reducing agent.

First aid

If this chemical gets into the eyes, remove any con-tact lenses at once and irrigate immediately for at least 15 min,occasionally lifting upper and lower lids. Seek medical atten-tion immediately. If this chemical contacts the skin, removecontaminated clothing and wash immediately with soap andwater. Seek medical attention immediately. If this chemicalhas been inhaled, remove from exposure, begin rescue breath-ing (using universal precautions, including resuscitation mask)if breathing has stopped and CPR if heart action has stopped.Transfer promptly to a medical facility. When this chemicalhas been swallowed, get medical attention. If victim is con-scious, administer water or milk. Do not induce vomiting.Note to physician: Treat for methemoglobinemia. Test urineformethemoglobinemia. Spectrophotometry may berequired for precise determination of levels of methemoglo-bin in urine.

Carcinogenicity

Carcinogenicity of hydroxylamine and its salts has not been demonstrated. Several studies have shown a decreased incidence of spontaneous mammary tumors in mice exposed to the sulfate and hydrochloride.3–7 There was some indication of an increase in the incidence of spontaneous mammary tumors when the sulfate was administered to older animals whose mammary glands were already well developed.

Environmental Fate

The large-scale production and use of hydroxylamine may result in its release to the environment through various waste streams. Hydroxylamine will exist solely as a vapor in the ambient atmosphere, and will be degraded in the atmosphere by reaction with photochemically produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 18 h.
Abiotic degradation of hydroxylamine by photochemically produced peroxy radicals is an important environmental fate process in surface waters, with the half-life of the reaction measured at approximately 2 h. An estimated bioconcentration factor of 3 suggests that the potential for bioconcentration in aquatic organisms is low. If released terrestrially, hydroxylamine will most likely exist in its protonated form due to its pKa of 5.94; the protonated form is nonvolatile. Koc estimates of 14 for hydroxylamine suggest that it may have very high mobility in soil.

storage

(1) Color Code- Yellow Stripe (strong reducingagent): Reactivity Hazard; Store separately in an area iso-lated from flammables, combustibles, or other yellow-codedmaterials. (2) Color Code- Blue: Health Hazard/Poison:Store in a secure poison location. Prior to working with thischemical you should be trained on its proper handling andstorage. Protect against physical damage. Store in cool, non-combustible buildings and separate from oxidizing materi-als. Open airtight containers occasionally to relieve pressurefrom decomposition products.

Shipping

Toxic solid, corrosive, inorganic, n.o.s. requires ashipping label of“POISONOUS/TOXIC MATERIALS,CORROSIVE.”It falls in DOT/UN Hazard Class 6.1 andPacking Group II.

Purification Methods

Crystallise it from n-butanol at -10o, collect it by vacuum filtration and wash it with cold diethyl ether. Harmful vapours. [Hurd Inorg Synth I 87 1939, Semon in Org Synth Coll Vol I 318 1932.]

Toxicity evaluation

Hydroxylamine acts as a reducing agent when absorbed systemically, producing methemoglobin and the formulation of Heinz bodies in the blood. It can induce hemolytic anemia. It inhibits platelet aggregation and is a nitric oxide vasodilator. Oxylamines such as hydroxylamine and methoxylamine disturb DNA replication and act as potent mutagens, causing nucleotide transition from one purine to another or one pyrimidine to another.
Allergic reactions of the skin following dermal exposure to hydroxylamine resemble contact eczema, or possibly urticaria of Quincke’s edema. The pathogenesis of this reaction appears to be mediated by a delayed type T-lymphocyte reaction.

Incompatibilities

Self reactive. Contaminants, tempera-tures above 129.4℃, or open flame can cause explosivedecomposition, especially in the presence of moisture andcarbon dioxide. Incompatible with strong acids, organicanhydrides, isocyanates, aldehydes, sodium, finely dividedzinc, some metal oxides. Aqueous solution is a weak base.Contact with strong oxidizers may cause a fire and explo-sion hazard. Attacks some metals. Contact with calcium orzinc forms a heat-sensitive explosive [bis(hydroxylamide)](Sax).

Properties of HYDROXYLAMINE

Melting point: 7°C
Boiling point: >100 °C
Density  1.078 g/mL at 25 °C
vapor pressure  9 mm Hg ( 40 °C)
refractive index  n20/D 1.393
RTECS  NC2975000
storage temp.  Store below +30°C.
solubility  Water
form  white flakes or needles
pka pK (20°) 7.97
color  white orthorhombic flakes or needles
Water Solubility  Miscible with water, liquid ammonia and methanol. Slightly miscible with ether, benzene, carbon disulfide and chloroform.
Merck  13,4853
Stability: Stable. Incompatible with oxidizing agents, potassium dichromate, chromium trioxide, zinc, calcium, copper, sodium, ammonia, carbonyls, phosphorus halides, pyridine, hypochlorites.
CAS DataBase Reference 7803-49-8(CAS DataBase Reference)
NIST Chemistry Reference Hydroxylamine(7803-49-8)
EPA Substance Registry System Hydroxylamine (7803-49-8)

Safety information for HYDROXYLAMINE

Signal word Danger
Pictogram(s)
ghs
Flame
Flammables
GHS02
ghs
Corrosion
Corrosives
GHS05
ghs
Exclamation Mark
Irritant
GHS07
ghs
Health Hazard
GHS08
ghs
Environment
GHS09
GHS Hazard Statements H290:Corrosive to Metals
H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H317:Sensitisation, Skin
H318:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
H351:Carcinogenicity
H373:Specific target organ toxicity, repeated exposure
H400:Hazardous to the aquatic environment, acute hazard
Precautionary Statement Codes P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P230:Keep wetted with …
P233:Keep container tightly closed.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P371+P380+P375:in case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
P501:Dispose of contents/container to..…

Computed Descriptors for HYDROXYLAMINE

InChIKey AVXURJPOCDRRFD-UHFFFAOYSA-N

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