2-Nitrofluorene

CAS NO.：607-57-8
Empirical Formula: C13H9NO2
Molecular Weight: 211.22
MDL number: MFCD00001117
EINECS: 210-138-5
SAFETY DATA SHEET (SDS)
Update Date: 2023-04-23 13:52:06

What is 2-Nitrofluorene?

Chemical properties

cream powder

The Uses of 2-Nitrofluorene

2-Nitrofluorene is a genotoxic compound and also a biomaker that affects the DNA of living organisms. An environmental pollutant.

What are the applications of Application

2-Nitrofluorene is a nitrated polycyclic aromatic hydrocarbon

Definition

ChEBI: A nitroarene that is fluorene substituted by a nitro group at position 2.

General Description

Cream-colored solid.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Aromatic nitro compounds, such as 2-Nitrofluorene, range from slight to strong oxidizing agents. If mixed with reducing agents, including hydrides, sulfides and nitrides, they may begin a vigorous reaction that culminates in a detonation. The aromatic nitro compounds may explode in the presence of a base such as sodium hydroxide or potassium hydroxide even in the presence of water or organic solvents. The explosive tendencies of aromatic nitro compounds are increased by the presence of multiple nitro groups. Stable under normal conditions. Protect from bases.

Health Hazard

ACUTE/CHRONIC HAZARDS: Toxic. Hazardous decomposition products. Carcinogen.

Safety Profile

Confirmed carcinogen with experimental carcinogenic and tumorigenic data. Moderately toxic by intraperitoneal route. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also NITRO COMPOUNDS OF AROMATIC HYDROCARBONS.

Metabolic pathway

Lung microsomal metabolism of 2-nitrofluorene (NF) increases in parallel with the accumulation of P-450b homologous mRNA and microsomal cytochrome P- 450b protein concentration. The formation of the major metabolite, and potent mutagen, 9-hydroxy-2- nitrofluorene (9-OHNF) is significantly inhibited by the addition of polyclonal anti-P-450b-IgG, and by the addition of the inhibitor, proadifen, to incubations with lung microsomal protein.

Purification Methods

Crystallise 2-nitrofluorene from aqueous acetic acid or Me2CO (m 158-158.5o, also 160-160.5o). [Beilstein 5 H 628, 5 III 1948.]

Properties of 2-Nitrofluorene

Melting point:	156-158 °C (lit.)
Boiling point:	350.9°C (rough estimate)
Density	1.1868 (rough estimate)
refractive index	1.6060 (estimate)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
form	Powder
color	White to brown
Water Solubility	Insoluble
Stability:	Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference	607-57-8(CAS DataBase Reference)
IARC	2B (Vol. 46, 105) 2014
NIST Chemistry Reference	Fluorene, 2-nitro-(607-57-8)
EPA Substance Registry System	2-Nitrofluorene (607-57-8)

Safety information for 2-Nitrofluorene

Signal word	Warning
Pictogram(s)	Health Hazard GHS08 Environment GHS09
GHS Hazard Statements	H351:Carcinogenicity H411:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P201:Obtain special instructions before use. P273:Avoid release to the environment. P308+P313:IF exposed or concerned: Get medical advice/attention.