2,4,7-TRINITRO-9-FLUORENONE

The Uses of 2,4,7-TRINITRO-9-FLUORENONE

Tumor Necrosis Factor-α from mouse, a potent proinflammatory cytokine has been used:

• to activate MS1 endothelium cells
• to induce lipolysis in adipocytes
• to study its effect on liganded and unliganded glucocorticoid receptor (GR) in interleukin (IL)-6 and IL-8 gene regulation

The Uses of 2,4,7-TRINITRO-9-FLUORENONE

TNF-α influences the growth and function of both normal and neoplastic cells. TNF-α causes cytolysis or cytostasis of certain transformed cells being synergistic with γ-interferon in its cytotoxicity.

General Description

Pale yellow needles (from acetic acid or benzene) or yellow powder.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Literature sources indicate that 2,4,7-TRINITRO-9-FLUORENONE is flammable. . Aromatic nitrates range from slight to strong oxidizing agents. If mixed with reducing agents, including hydrides, sulfides and nitrides, they may begin a vigorous reaction.

Hazard

Suspected carcinogen. Mildly toxic by ingestion. A skin and eye irritant.

Fire Hazard

Literature sources indicate that 2,4,7-TRINITRO-9-FLUORENONE is flammable.

Biochem/physiol Actions

The TNFA (tumor necrosis factor α) gene is significantly associated with the regulation of innate and adaptive immune responses. Polymorphism of TNFA gene is known to cause acute motor axonal neuropathy. The cytokine release and gene action is associated with epithelial cells, myeloid cells, endothelial, as well as tumor cells. Tumor cells are known to release TNFA, specifically in response to chemotherapy

Safety Profile

Suspected carcinogen with experimental tumorigenic data. Mildly toxic by ingestion. Human mutation data reported. A skin and eye irritant. When heated to decomposition it emits hghly toxic fumes of NOx. See also NITRO COMPOUNDS of AROMATIC HYDROCARBONS and KETONES.

Purification Methods

Crystallise it from nitric acid/water (3:1), wash it with water and dry it under vacuum over P2O5, or recrystallise it from dry *benzene. [Beilstein 7 II 410, 7 III 2348, 7 IV 1638.]