HYDROXYFLUTAMIDE
Synonym(s):2-Hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]-propanamide;2-Hydroxyflutamide;a,a,a-Trifluoro-2-methyl-4′-nitro-m-lactotoluidide;Hydroxyniphtholide;Sch 16423
- CAS NO.:52806-53-8
- Empirical Formula: C11H11F3N2O4
- Molecular Weight: 292.21
- MDL number: MFCD00563126
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-07 13:31:19
What is HYDROXYFLUTAMIDE?
Description
2-
Chemical properties
HYDROXYFLUTAMIDE is Yellow-Brown Powder
The Uses of HYDROXYFLUTAMIDE
Shown to be an antianhydrogen. The active metabolite of the widely used non-steroidal antagonist flutamide
The Uses of HYDROXYFLUTAMIDE
The active metabolite of the widely used non-steroidal antagonist Flutamide (F598850). Shown to be an antianhydrogen.
The Uses of HYDROXYFLUTAMIDE
HYDROXYFLUTAMIDE is used non-steroidal antagonist Flutamide. Shown to be an antianhydrogen.
What are the applications of Application
2-Hydroxy-flutamide is an inhibitor of proliferation of estradiol-induced growth of MCF-7 breast cancer cells
Biochem/physiol Actions
Hydroxyflutamide plays a role in preventing the binding of 5α-dihydrotestosterone (DHT) and testosterone to the androgen receptors.
References
[1] kolvenbag g, furr b j a, blackledge g r p. receptor affinity and potency of non-steroidal antiandrogens: translation of preclinical findings into clinical activity[j]. prostate cancer and prostatic diseases, 1998, 1: 307-314.
[2] heinlein c a, chang c. androgen receptor in prostate cancer[j]. endocrine reviews, 2004, 25(2): 276-308.
[3] shet m s, mcphaul m, fisher c w, et al. metabolism of the antiandrogenic drug (flutamide) by human cyp1a2[j]. drug metabolism and disposition, 1997, 25(11): 1298-1303.
[4] gao w, kim j, dalton j t. pharmacokinetics and pharmacodynamics of nonsteroidal androgen receptor ligands[j]. pharmaceutical research, 2006, 23(8): 1641-1658.
Properties of HYDROXYFLUTAMIDE
Melting point: | 125-130°C |
Boiling point: | 443.8±45.0 °C(Predicted) |
Density | 1.472 |
storage temp. | room temp |
solubility | DMSO: >10mg/mL |
pka | 12.87±0.70(Predicted) |
form | powder |
color | white to tan |
Safety information for HYDROXYFLUTAMIDE
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for HYDROXYFLUTAMIDE
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