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HomeProduct name listHycanthone

Hycanthone

  • CAS NO.:3105-97-3
  • Empirical Formula: C20H24N2O2S
  • Molecular Weight: 356.48
  • MDL number: MFCD00083383
  • EINECS: 221-463-7
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-07 13:31:19
Hycanthone Structural

What is Hycanthone?

The Uses of Hycanthone

Hycanthone is the active metabolite of the anthelmintic prodrug Lucanthone (L473700), which is used in the treatment of schistosomiasis.

The Uses of Hycanthone

Antischistosomal.

Definition

ChEBI: A thioxanthen-9-one compound having a hydroxymethyl substituent at the 1-position and a 2-[(diethylamino)ethyl]amino substituent at the 4-position. It was formerly used (particularly as the monomethanesulfonic acid salt) as a schistosomicide for individual or mass treatement of infection with Schistosoma haematobium and S. mansoni, but due to its toxicity and concern about possible carcinogenicity, it has been replaced by other drugs such as praziquantel.

General Description

Odorless canary yellow to yellow-orange crystalline powder. Bitter taste.

Air & Water Reactions

1-[(2-[DIETHYLAMINO]ETHYL)AMINO]-4-[HYDROXYMETHYL]-9H-THIOXANTHEN-9-ONE may be sensitive to prolonged exposure to air and light. Highly soluble in water.

Reactivity Profile

1-[(2-[DIETHYLAMINO]ETHYL)AMINO]-4-[HYDROXYMETHYL]-9H-THIOXANTHEN-9-ONE is very sensitive to acid. .

Fire Hazard

Flash point data for 1-[(2-[DIETHYLAMINO]ETHYL)AMINO]-4-[HYDROXYMETHYL]-9H-THIOXANTHEN-9-ONE are not available; however, 1-[(2-[DIETHYLAMINO]ETHYL)AMINO]-4-[HYDROXYMETHYL]-9H-THIOXANTHEN-9-ONE is probably combustible.

Safety Profile

Poison by subcutaneous, intravenous, and intramuscular routes. Moderately toxic by ingestion. Experimental teratogenic effects. Human mutation data reported. Questionable carcinogen with experimental carcinogenic data. When heated to decomposition it emits very toxic fumes of NOx and SOx.

Properties of Hycanthone

Melting point: 100.6-102.8°
Boiling point: 570.5±50.0 °C(Predicted)
Density  1.1269 (rough estimate)
refractive index  1.6000 (estimate)
storage temp.  Keep in dark place,Sealed in dry,2-8°C
solubility  DMSO : 30 mg/mL (84.16 mM)
pka pKa 3.40 (Uncertain)
form  Solid
color  Yellow to orange
EPA Substance Registry System Hycanthone (3105-97-3)

Safety information for Hycanthone

Computed Descriptors for Hycanthone

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