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HomeProduct name listHonokiol

Honokiol

Synonym(s):5,3ʹ-Diallyl-2,4ʹ-dihydroxydiphenyl, VEGFR Tyrosine Kinase Inhibitor XIX, VEGFR2 Kinase Inhibitor XV;5,3′-Diallyl-2,4′-dihydroxybiphenyl;Honokiol - CAS 35354-74-6 - Calbiochem;NSC 293100

  • CAS NO.:35354-74-6
  • Empirical Formula: C18H18O2
  • Molecular Weight: 266.33
  • MDL number: MFCD00016674
  • EINECS: 609-119-8
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-06 15:28:16
Honokiol Structural

What is Honokiol?

Description

Magnolol is derived from the root bark and branch bark of magnolia or Magnolia officinalis. Magnolia officinalis was first written in the《ben jing》, it prefers cool and humid climate and well-drained acid soil. Cortex magnoliae officinalis (hou po) is mainly produced in Sichuan (Wan quan, Shizhu, Guanxian), Hubei (Shien,Yichang, Lichuan), Zhejiang (Longquan, Anhui), and other places. It is also distributed in Fujian, Jiangxi, Hunan, Guangxi, Yunnan, Guizhou, Shanxi, Gansu, and other places. Cortex magnoliae officinalis from Sichuan and Hubei is called “chuan pu,” with better quality, while in Zhejiang, it is called “warm park,” with a larger output.

Physical properties

Appearance: white fine powder. Solubility: practically insoluble in water; very soluble in benzene, ethyl ether, chloroform, and acetone. Melting point: magnolol is 102 °C. Honokiol is 87.5 °C.

History

In 1930, magnolol was first isolated from the bark of Cortex magnoliae officinalis in China by Japanese Sugii, and it was also isolated from Cortex magnoliae officinalis in Japan. In 1973, magnolol and its isomers honokiol were isolated from Cortex magnoliae officinalis in China and Japan by Japanese Fujita.
The drug research and development of magnolol and honokiol remain in pharmacological activity and preclinical research. Kyung Hee University from Korea declared a preclinical study in 2003, in which allergy, anxiety, angina, and heart failure are indications for honokiol.

The Uses of Honokiol

Honokiol is a small-molecule polyphenol isolated from the genus Magnolia. Recent studies show that Honokiol displays antiangiogenic, antiinflammatory, and antitumor properties in preclinical models, w ithout appreciable toxicity. Honokiol has been shown to inhibit the bone metastatic growth of human prostate cancer cells.

The Uses of Honokiol

Honokiol has been used:

  • to study its effects on plasmid hSirt3102-399 deacetylation activity
  • as an antioxidant to study its cytoprotective role in human ovarian cancer cells (SKOV-3) and Chinese hamster ovary cells (CHOK1)
  • to explore its effects on oxidative stress and mitochondrial dysfunction via a sirt3-dependent manner
  • for intracerebroventricular (ICV) cannulation

What are the applications of Application

Honokiol is a biphenyl neolignan from Magnolia extract that inhibits phosphorylation of Akt, p44/42 MAPK, and src

Indications

These compounds are recorded in the British Pharmacopoeia (2017) and European Pharmacopoeia (8.7th ed.). They are mainly used as antibacterial and antifungal agents.

Definition

ChEBI: Honokiol is a member of biphenyls.

General Description

Honokiol exhibits analgesic, antithrombotic, antispasmodic, antidepressant, antimicrobial and neuroprotective effects. It regulates gamma-aminobutyric acid (GABA) A receptors. Honokiol is associated with an increased risk of bleeding. It prevents platelet aggregation, protects myocardium from ischemic damage and inhibits ventricular arrhythmia.

Biochem/physiol Actions

Honokiol is a natural biphenyl neolignan from magnolia extract. It is antiangiogenic, antitumor, and anxiolytic.

Pharmacology

Magnolol and honokiol have the pharmacological effects of prolonging central muscle relaxation, inhibition of the central nervous, anti-inflammatory, antibacterial, antimicrobial, antiulcer, antioxidant, antitumor, hormone regulation, and antidiabetes .

storage

+4°C

Properties of Honokiol

Melting point: 86℃
Boiling point: 400.1±40.0 °C(Predicted)
Density  1.107±0.06 g/cm3(Predicted)
storage temp.  2-8°C
solubility  DMSO: 36 mg/mL
form  powder
pka 9.89±0.48(Predicted)
color  White to Off-White
Merck  14,4742
Stability: Light Sensitive
CAS DataBase Reference 35354-74-6(CAS DataBase Reference)

Safety information for Honokiol

Signal word Danger
Pictogram(s)
ghs
Corrosion
Corrosives
GHS05
ghs
Environment
GHS09
GHS Hazard Statements H318:Serious eye damage/eye irritation
H411:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes P273:Avoid release to the environment.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P391:Collect spillage. Hazardous to the aquatic environment
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P501:Dispose of contents/container to..…

Computed Descriptors for Honokiol

InChIKey FVYXIJYOAGAUQK-UHFFFAOYSA-N

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