HL 725
Synonym(s):9,10-Dimethoxy-2-mesitylimino-3-methyl-2,3,6,7-tetrahydro-4H-pyrimido-(6,1-a)-isoquinolin-4-one, HCl, HL 725;HL 725;Trequinsin, Hydrochloride - CAS 78416-81-6 - Calbiochem
- CAS NO.：78416-81-6
- Empirical Formula: C24H28ClN3O3
- Molecular Weight: 441.95
- MDL number: MFCD01076563
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-15 19:19:13
What is HL 725?
The Uses of HL 725
PDE inhibitor
The Uses of HL 725
Trequinsin Hydrochloride is an ultrapotent inhibitor of phosphodiesterase (PDE) 3.
What are the applications of Application
Trequinsin hydrochloride is an ultrapotent inhibitor of phosphodiesterase 3
Biological Activity
Extremely potent inhibitor of cGMP-inhibited phosphodiesterase (PDE3; IC 50 = 250 pM). Potently inhibits arachidonic acid-induced aggregation of human platelets (IC 50 = 50 pM). Orally active antihypertensive agent; reduces systemic blood pressure in both normotensive and hypertensive animal models.
storage
Desiccate at RT
Properties of HL 725
| Melting point: | 210-211 °C(Solv: ethanol (64-17-5); ethyl ether (60-29-7)) |
| storage temp. | Desiccate at RT |
| solubility | DMSO: 100 mM; Ethanol: 100 mM |
| form | Pale yellow solid |
| color | Light yellow to yellow |
Safety information for HL 725
Computed Descriptors for HL 725
New Products
4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Mefenamic Acid IP/BP/EP/USP Diclofenac Sodium IP/BP/EP/USP Ornidazole IP Diclofenac Potassium SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
![(4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE](https://img.chemicalbook.in/CAS/GIF/85416-75-7.gif)
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