HISPIDULIN
Synonym(s):Dinatin;6-Methoxyapigenin;6-Methylscutellarein;Salvitin;Scutellarein 6-methyl ether
- CAS NO.:1447-88-7
- Empirical Formula: C16H12O6
- Molecular Weight: 300.26
- MDL number: MFCD00143504
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-08 09:02:10
What is HISPIDULIN?
The Uses of HISPIDULIN
Hispidulin has been used as a calibration standard:
- in high-performance liquid chromatography (HPLC) for quantification of Clerodendrum petasites flavonoids
- in liquid chromatography/electrospray ionization mass spectrometry (LC/ESI-MS) analysis
- in reverse-phase high-performance liquid chromatography with a diode-array detector (HPLC-DAD) and high-performance thin-layer chromatography (HPTLC)
What are the applications of Application
Hispidulin is a potent benzodiazepine (BZD) receptor ligand
Definition
ChEBI: A monomethoxyflavone that is scutellarein methylated at position 6.
General Description
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
Biological Activity
Partial positive allosteric modulator at the benzodiazepine receptor (IC 50 = 1.3 μ M for inhibition of flumazenil binding); natural sage flavone. Stimulates GABA-induced chloride currents in Xenopus oocytes expressing α 1 α 2-, α 3-, α 5- or α 6- β 2 γ 2S GABA A receptors. Brain penetrant; oral administration reduces seizures in a gerbil model of epilepsy. Also has antifungal, antiproliferative, antioxidant and antithrombotic properties.
Biochem/physiol Actions
Hispidulin is a bioactive flavonoid with a variety of effects including antiproliferative, antifungal, anti-inflammatory, antioxidative and antiepileptic activity. Like EGCG, hispidulin appears to activate AMPK and inhibit the PI3K/Akt/mTOR pathway. The antiepileptic activity may be due to additional activity as a benzodiazepine (BZD) receptor ligand.
Properties of HISPIDULIN
Melting point: | 291-292 °C |
Boiling point: | 601.5±55.0 °C(Predicted) |
Density | 1.512±0.06 g/cm3(Predicted) |
storage temp. | -20°C |
solubility | DMSO: soluble20mg/mL, clear |
form | powder |
pka | 6.51±0.40(Predicted) |
color | white to beige |
Safety information for HISPIDULIN
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral |
Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for HISPIDULIN
New Products
Tubulysin F Tubulysin E Tubulysin C Tubulysin G Potassium HMDS (1.0 M in THF) 4,4-DIFLUOROPIPERIDINE 2H-Pyran, 4-ethynyltetrahydro- 1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE Isoxazole, 3-[[[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]thio]-4,5-dihydro-5,5-dimethyl- Methyl (R)-1-Boc-4,4-difluoropyrrolidine-2-carboxylate 2-(azetidin-3-ylidene)acetonitrile (hydrochloride) Calcium Sodium Phosphosilicate IH 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Imeglimin Hydrochloride IH Fuel shell 4-(2-fluoro-4- nitrophenyl) thiomorpholine 2,3-dichloro-6- nitrobenzonitrile Magnesium Trisilicate Latanoprostene Bunod Lubiprostone Flame Retardant Zinc Borate 7-Methoxyquinoline-4-carbonitrileRelated products of tetrahydrofuran
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