Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name listHeptafluorobutyric acid

Heptafluorobutyric acid

Synonym(s):Heptafluorobutyric acid;HFBA;Perfluorobutyric acid;HFBA solution;Perfluorobutbutyric acid solution

  • CAS NO.:375-22-4
  • Empirical Formula: C4HF7O2
  • Molecular Weight: 214.04
  • MDL number: MFCD00004171
  • EINECS: 206-786-3
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-04-23 13:52:06
Heptafluorobutyric acid Structural

What is Heptafluorobutyric acid?

Chemical properties

Clear colorless to faintly yellow liquid

The Uses of Heptafluorobutyric acid

Heptafluorobutyric acid (HBFA) has been used widely for purifying neuropeptides because of its excellent resolution. The use of heptafluorobutyric acid as a volatile ion-pair reagent in the high-performance liquid chromatographic isolation of SB-223070 John K.
Heptafluorobutyric acid is a strong acid and ion-pairing agent that is used in analytical chemistry, notably in HPLC and in gas chromatography/mass spectrometry (GC/MS), in a similar manner to trifluoroacetic acid (TFA). The strong acidity of HFBA ensures that other acidic groups such as carboxylic acid moieties on biomolecules remain protonated, and thus the biomolecule samples are able to interact with organic solvents in such processes as reverse phase chromatography. The longer alkyl chain of HFBA makes it more hydrophobic than TFA, and thus HFBA can be utilized with more hydrophobic samples.
HFBA (0.1%) has been used in the mobile phase of an HPLC/LC-MS protocol for the detection of marine bacterioplankton sideophores.A study of the effects of various acids, including HFBA, on the resolution of intact proteins by reversed-phase LC/ESI-MS has been published.A modified version of the peptide ladder sequencing technique that incorporates allyl isothiocyanate and HFBA has been reported.

The Uses of Heptafluorobutyric acid

Heptafluorobutyric acid is an ion pair reagent for reverse-phase HPLC. It is used in the sequencing, synthesis, and solubilizing of proteins and peptides. It is used as mobile phase modifier for enhancement of selectivity in the HPLC analysis of histone proteins. It is an effective additive for zinc electrodeposition.

The Uses of Heptafluorobutyric acid

Perfluorobutyric acid was used as mobile phase modifier for enhancement of selectivity in the HPLC analysis of histone proteins. It was used as ion pairing reagent in preparative and analytical reserved phase HPLC of underivatised peptides.

What are the applications of Application

Heptafluorobutyric acid is an anion-pairing agent for reverse phase HPLC purification of proteins & peptides

Definition

ChEBI: A monocarboxylic acid that is perfluorinated butyric acid.

General Description

Perfluorobutyric acid is an effective additive for zinc electrodeposition.

Hazard

Irritant to tissue.

Purification Methods

Fractionally distil the acid twice in an Oldershaw column (p 10) with an automatic vapour-dividing head, the first distillation being in the presence of conc H2SO4 as a drying agent. (Take care with the hot acid.) [Beilstein 2 IV 810.]

Properties of Heptafluorobutyric acid

Melting point: -17.5 °C
Boiling point: 120 °C755 mm Hg(lit.)
Density  1.645 g/mL at 25 °C(lit.)
vapor density  7 (vs air)
vapor pressure  ~10 mm Hg ( 25 °C)
refractive index  n20/D 1.3(lit.)
Flash point: 120-121°C
storage temp.  Store below +30°C.
solubility  Chloroform: soluble; Methanol: soluble
pka pK1:0.17 (25°C)
form  Powder
color  Clear colorless to faint yellow
Specific Gravity approximate 1.6
PH 1 (H2O, 20℃)
Water Solubility  miscible
Sensitive  Light Sensitive
BRN  1426882
CAS DataBase Reference 375-22-4(CAS DataBase Reference)
NIST Chemistry Reference Butanoic acid, heptafluoro-(375-22-4)
EPA Substance Registry System Heptafluorobutyric acid (375-22-4)

Safety information for Heptafluorobutyric acid

Signal word Danger
Pictogram(s)
ghs
Corrosion
Corrosives
GHS05
GHS Hazard Statements H314:Skin corrosion/irritation
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.
P363:Wash contaminated clothing before reuse.
P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Heptafluorobutyric acid

InChIKey YPJUNDFVDDCYIH-UHFFFAOYSA-N

Related products of tetrahydrofuran

You may like

  • Heptafluorobutyric acid 98%
    Heptafluorobutyric acid 98%
    View Details
  • Heptafluorobutyric Acid CAS 375-22-4
    Heptafluorobutyric Acid CAS 375-22-4
    375-22-4
    View Details
  • Perfluorobutyric Acid CAS
    Perfluorobutyric Acid CAS
    View Details
  • Heptafluorobutyric acid, 99% CAS 375-22-4
    Heptafluorobutyric acid, 99% CAS 375-22-4
    375-22-4
    View Details
  • Heptafluorobutyric Acid [Sequenation Reagent] CAS 375-22-4
    Heptafluorobutyric Acid [Sequenation Reagent] CAS 375-22-4
    375-22-4
    View Details
  • Heptafluorobutyric Acid (ca. 0.5mol/L in Water) [Ion-Pair Reagent for LC-MS] CAS 375-22-4
    Heptafluorobutyric Acid (ca. 0.5mol/L in Water) [Ion-Pair Reagent for LC-MS] CAS 375-22-4
    375-22-4
    View Details
  • Heptafluorobutyric acid 98% CAS 375-22-4
    Heptafluorobutyric acid 98% CAS 375-22-4
    375-22-4
    View Details
  • Heptafluorobutyric acid CAS 375-22-4
    Heptafluorobutyric acid CAS 375-22-4
    375-22-4
    View Details
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.