Hederagenin
Synonym(s):3,23-Dihydroxyolean-12-en-28-acid;Astrantiagenin E;Caulosapogenin;Hederagenic acid;Hederagenol
- CAS NO.:465-99-6
- Empirical Formula: C30H48O4
- Molecular Weight: 472.71
- MDL number: MFCD00017385
- EINECS: 207-369-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-01-03 18:42:19
What is Hederagenin?
Description
Hederagenin is a triterpene saponin that has been found in P. eximia with diverse biological activities. It increases production of reactive oxygen species (ROS), reduces colony formation, and induces apoptosis in cisplatin-resistant head and neck carcinoma (HNC) cells. In vivo, hederagenin (50, 100, and 200 mg/kg) suppresses tumor growth in a cisplatin-resistant HNC mouse xenograft model. It reduces aortic atherosclerotic lesion area, serum cholesterol and LDL levels, and inducible nitric oxide synthase (iNOS) protein levels in a rat model of atherosclerosis. Hederagenin (50 mg/kg) reduces ethanol-induced production of TNF-α, IL-6, and COX-2, alcohol dehydrogenase 2 (ALDH2) mRNA expression, and liver damage in a rat model of alcohol-induced hepatotoxicity. It also induces autophagy and inhibits oligomerization of α-synuclein in a mouse model of Parkinson''s disease induced by MPTP.
Chemical properties
White Solid
The Uses of Hederagenin
Triterpenoid which can inhibit the proliferation of leukemia HL-60 cells.
Definition
ChEBI: A sapogenin that is olean-12-en-28-oic acid substituted by hydroxy groups at positions 3 and 23 (the 3beta stereoisomer).
Properties of Hederagenin
Melting point: | 332-334° |
Boiling point: | 493.44°C (rough estimate) |
alpha | D20 +81° (c = 0.7 in pyridine) |
Density | 0.9871 (rough estimate) |
refractive index | 1.4800 (estimate) |
storage temp. | Sealed in dry,2-8°C |
solubility | methanol: soluble1mg/mL |
form | Solid |
pka | 4.63±0.70(Predicted) |
color | White to Off-White |
λmax | 405nm(H2SO4)(lit.) |
Merck | 14,4624 |
Safety information for Hederagenin
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral |
Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P501:Dispose of contents/container to..… |
Computed Descriptors for Hederagenin
InChIKey | PGOYMURMZNDHNS-MYPRUECHSA-N |
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