H-LEU-4M-BETANA HCL
- CAS NO.:4467-68-9
- Empirical Formula: C17H23ClN2O2
- Molecular Weight: 322.83
- MDL number: MFCD00034967
- EINECS: 2247353
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-18 11:31:00
What is H-LEU-4M-BETANA HCL?
Description
L-Leucine 4-methoxy-β-naphthylamide is a cell-permeable substrate for aminopeptidase M and leucine aminopeptidase that was developed for intracellular analysis of protease activities.
Chemical properties
Crystalline
The Uses of H-LEU-4M-BETANA HCL
L-Leucine 4-methoxy-β-naphthylamide is a cell-permeable substrate for aminopeptidase M and leucine aminopeptidase that was developed for intracellular analysis of protease activities.
in vitro
l-leucine 4-methoxy-β-naphthylamide was identified as a cell-permeable substrate for aminopeptidase m and leucine aminopeptidase that was developed for intracellular analysis of protease activities [1]. in a previous method-developing study, peptide derivatives of 4-methoxy-β-naphthylamine including l-leucine 4-methoxy-β-naphthylamide were incubated in microtiter plates together with nitrosalicylaldehyde. selectivity was achieved by running parallel assays containing inhibitors partially selective for each of peptide derivatives. this method was successfully validated by measurements in cells isolated from cathepsin b-/--, k-/--, and l-/-- mice [2].
References
[1] monis, b. ,wasserkrug, h. and seligman, a.m. comparison of fixatives and substrates for aminopeptidase. journal of histochemistry and cytochemistry 13(6), 503-509 (1965).
[2] rüttger, a. ,mollenhauer, j.,lser, r., et al. microplate assay for quantitative determination of cathepsin activities in viable cells using derivatives of 4-methoxy-β-naphthylamide. biotechniques 41(4), 469-473 (2006).
Properties of H-LEU-4M-BETANA HCL
storage temp. | 2-8°C |
solubility | ≤25mg/ml in ethanol;10mg/ml in DMSO;20mg/ml in dimethyl formamide |
form | crystalline solid |
Safety information for H-LEU-4M-BETANA HCL
Signal word | Warning |
Pictogram(s) |
Health Hazard GHS08 |
GHS Hazard Statements |
H351:Carcinogenicity |
Precautionary Statement Codes |
P281:Use personal protective equipment as required. |
Computed Descriptors for H-LEU-4M-BETANA HCL
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