Glycinamide hydrochloride

Chemical properties

Crystalline

The Uses of Glycinamide hydrochloride

Glycinamide hydrochloride is a buffer that is useful in the physiological pH range. And it is also used as a pharmaceutical intermediate, in the organic synthesis.

The Uses of Glycinamide hydrochloride

Glycinamide hydrochloride may be used in the synthesis of [M(glycinamidato-N,N′)(ptpy)₂] where ptpy = 2-(p-tolyl)pyridinato) and M= Rh or Ir.
It may be used in the synthesis of the following glycinamide-based imidazolidinones:

• (±)-2-(2-phenylpropyl)imidazolidin-4-one
• (±)-2-(2,4,4-trimethylpentyl)imidazolidin-4-one
• (±)-2-[(R)-2,6-dimethyl-5-heptenyl]imidazolidin-4-one
• (5R,6S,9R)-6-isopropyl-9-methyl-1,4-diazaspiro[4.5]decan-2-one
• (5S,6S,9R)-6-isopropyl-9-methyl-1,4-diazaspiro[4.5]decan-2-one
• (±)-2-methyl-2-pentylimidazolidin-4-one
• (±)-2-ethyl-2-(2-methylbutyl)imidazolidin-4-one
• (±)-2-(undecan-2-yl)imidazolidin-4-one
• (±)-2-pentylimidazolidin-4-one
• 2-(2,4-dimethylcyclohex-3-en-1-yl)imidazolidin-4-one

Purification Methods

Crystallise the salt from EtOH, EtOH/H2O or MeOH. [Karmas & Spoerri J Am Chem Soc 74 1580 1952, Beilstein 4 IV 2358.]