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HomeProduct name listH-7 DIHYDROCHLORIDE

H-7 DIHYDROCHLORIDE

Synonym(s):1-(5-Isoquinolinesulfonyl)-2-methylpiperazine, 2HCl;1-(5-Isoquinolinylsulfonyl)-2-methylpiperazine dihydrochloride;H-7 dihydrochloride;H-7, Dihydrochloride - CAS 108930-17-2 - Calbiochem;Isoquinoline-5-sulfonic 2-methyl-1-piperazide dihydrochloride

H-7 DIHYDROCHLORIDE Structural

What is H-7 DIHYDROCHLORIDE?

Chemical properties

White Crystalline Solid

The Uses of H-7 DIHYDROCHLORIDE

H-7 dihydrochloride has been used to study H-7-induced inhibition of contractility in rat embryo fibroblasts (REF52) cells and acts as a kinase inhibitor.

The Uses of H-7 DIHYDROCHLORIDE

A selective inhibitor of protein kinase C or cyclic-nucleotide-dependent protein kinases

What are the applications of Application

H-7, Dihydrochloride is an ATP-competitive Ser/Thr kinase inhibitor

Definition

ChEBI: A hydrochloride salt prepared from anileridine and two molar equivalents of hydrogen chloride.

General Description

A broad-based, cell-permeable, reversible, ATP-competitive serine-threonine kinase inhibitor. Potent inhibitor of myosin light chain kinase (Ki = 97 μM), protein kinase A (Ki = 3.0 μM), protein kinase C (Ki = 6 μM), and protein kinase G (Ki = 5.8 μM). Induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells. Also inhibits telomerase activity in quercetin-, H-89-, or herbimycin A-treated NPC-076 cells.

Biochem/physiol Actions

Target Ki: 3.0 μM, 97 μM, 6.0 μM, 5.8 μM against protein kinase A , myosin light chain kinase, protein kinase C , and protein kinase G, respectively

storage

Store at RT

Properties of H-7 DIHYDROCHLORIDE

Melting point: 215-225 °C
storage temp.  2-8°C
solubility  H2O: 20 mg/mL
form  Light yellow lyophilized solid
color  White to Off-White
BRN  5840763
CAS DataBase Reference 108930-17-2(CAS DataBase Reference)

Safety information for H-7 DIHYDROCHLORIDE

Computed Descriptors for H-7 DIHYDROCHLORIDE

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