GW0742

Synonym(s):4-[2-(3-Fluoro-4-trifluoromethyl-phenyl)-4-methyl-thiazol-5-ylmethylsulfanyl]- 2-methyl-phenoxy}-acetic acid

CAS NO.：317318-84-6
Empirical Formula: C21H17F4NO3S2
Molecular Weight: 471.49
MDL number: MFCD07369423
EINECS: 1532714-185-1
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-07 13:31:19

What is GW0742?

Description

GW0742 is a PPARδ/β agonist very similar in molecular structure to GW501516 (Cardarine) — with the exception of one atom. It is often mentioned in comparison with Cardarine. This drug is mostly used by athletes to improve their stamina. The fat affecting properties of GW0742 also make it a good promoter of energy in the body. Additionally, this drug helps increase the oxidative abilities of your body muscles.

Chemical properties

Light Yellow Solid

The Uses of GW0742

GW0742 is a small molecule agonist of the human Peroxisome Proliferator-Activated Recept δ (PPAR δ). It shows an EC50 of 1.1 nM against PPAR δ with 100-fold selectivity over the other human subtypes.

What are the applications of Application

GW 0742 is a potent and highly selective PPARβ agonist

Definition

ChEBI: GW 0742 is a monocarboxylic acid.

Biological Activity

GW 0742 is a potent and highly selective PPARδ agonist. EC50 values are 0.001, 1.1 and 2 μM for transactivation of human PPARδ, -α, and -γ receptors respectively. Neuroprotective in rat cerebellar granule neuronal cultures after brief (12-hour) exposure but exhibits inherent toxicity after prolonged (48-hour) incubation. Increases rate of fatty acid oxidation and protects against ischemia/reperfusion injury in neonatal and adult cardiomyocytes.

storage

Desiccate at +4°C

Properties of GW0742

Melting point:	134.5-135.5 °C
Boiling point:	591.5±60.0 °C(Predicted)
Density	1.46±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: >5 mg/mL
form	solid
pka	3.17±0.10(Predicted)
color	white
InChI	InChI=1S/C21H17F4NO3S2/c1-11-7-14(4-6-17(11)29-9-19(27)28)30-10-18-12(2)26-20(31-18)13-3-5-15(16(22)8-13)21(23,24)25/h3-8H,9-10H2,1-2H3,(H,27,28)