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HomeProduct name listGSK-LSD1

GSK-LSD1

Synonym(s):GSK-LSD1 (trans-racemic) dihydrochloride;rel- N-[(1R,2S)-2-Phenylcyclopropyl]-4-Piperidinamine hydrochloride (1:2)

  • CAS NO.:1431368-48-7
  • Empirical Formula: C14H20N2
  • Molecular Weight: 216.32
  • MDL number: MFCD28124398
  • Update Date: 2024-11-05 08:26:49
GSK-LSD1 Structural

What is GSK-LSD1?

The Uses of GSK-LSD1

GSK-LSD1 has been used as a lysine specific demethylase 1 (LSD1) inhibitor in mice to study sepsis-induced mortality. It has also been used as an inhibitor to study if the effect of phenelzine activation of human immunodeficiency virus (HIV) latency is caused due to LSD1.

The Uses of GSK-LSD1

GSK LSD1 Dihydrochloride is an irreversible mechanism-based inhibitor of LSD1. Lysine-specific demthylase 1 (LSD1) belonges to the flavin adenine dinucleotide (FAD) family-dependant amine oxidases that include MAOs and PAOs. Inhibits cell proliferation in cancer cell lines.

Biochem/physiol Actions

GSK-LSD1 is a potent and selective inhibitor of lysine specific demethylase 1 (LSD1). GSK-LSD1 potently inhibits proliferation of varies cancer cell lines by changing gene expression patterns. For full characterization details, please visit the GSK-LSD1 probe summary on the Structural Genomics Consortium (SGC) website.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

References

[1]. structural genomics consortium.http://www. thesgc.org/chemical-probes/lsd1.

Properties of GSK-LSD1

Boiling point: 347.4±42.0 °C(Predicted)
Density  1.07±0.1 g/cm3(Predicted)
storage temp.  2-8°C
solubility  H2O: soluble20mg/mL, clear
form  powder
pka 10.14±0.10(Predicted)
color  white to beige

Safety information for GSK-LSD1

Computed Descriptors for GSK-LSD1

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