GLYX 13

Synonym(s):L-Threonyl-L-prolyl-L-prolyl-L-threoninamide trifluoroacetate; Thr-Pro-Pro-Thr-NH2 trifluoroacetate;Rapastinel;TPPT-amide trifluoroacetate

CAS NO.：117928-94-6
Empirical Formula: C18H31N5O6
Molecular Weight: 413.47
MDL number: MFCD12912477
SAFETY DATA SHEET (SDS)
Update Date: 2024-04-16 18:29:06

What is GLYX 13?

The Uses of GLYX 13

Rapastinel is a novel antidepressant drug approved as an adjunctive therapy for the treatment of treatment-resistant major depressive disorder. It is a centrally active, intravenously administered (non-orally active) amidated tetrapeptide (Thr-Pro-Pro-Thr-NH2) that acts as a selective, weak partial agonist (mixed antagonist/agonist) of an allosteric site at the glycine site of the NMDA receptor complex (Emax ≈ 25%).The drug is a rapid-acting and long-lasting antidepressant as well as robust cognitive enhancer by virtue of its ability to both inhibit and enhance NMDA receptor-mediated signal transduction.

The Uses of GLYX 13

GLYX-13 is a long lasting and rapid acting antidepressant. Investigational drug for the treatment of depressive disoder.

The Uses of GLYX 13

GLYX-13 trifluoroacetate has been used as an activator of NMDA (N-methyl-D-aspartate) receptor.

Biochem/physiol Actions

GLYX-13 is a glycine-site functional partial agonist (GFPA) selective modulator of the NMDA receptor (NMDAR). It is a brain penetrable tetrapeptide which acts as a positive allosteric modulator of the NMDA receptor, acting via the glycine site. GLYX-13 has been found to be a cognitive enhancer in learning models and is currently in clinical trials as an antidepressant.

storage

Store at -20°C

Properties of GLYX 13

Boiling point:	844.2±65.0 °C(Predicted)
Density	1.370±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility	DMF: 25 mg/ml; DMSO: 15 mg/ml; Ethanol: 10 mg/ml; PBS (pH 7.2): 5 mg/ml
form	powder
pka	12.26±0.45(Predicted)
color	white to tan
Water Solubility	Soluble to 2 mg/ml in water

Safety information for GLYX 13

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.