GLUCAGON-LIKE PEPTIDE I FRAGMENT 7-36 AMIDE HUMAN
Synonym(s):Preproglucagon 78-107 Amide
- CAS NO.:107444-51-9
- Empirical Formula: C149H226N40O45
- Molecular Weight: 3297.68
- MDL number: MFCD00133373
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-11-02 11:53:15
What is GLUCAGON-LIKE PEPTIDE I FRAGMENT 7-36 AMIDE HUMAN?
The Uses of GLUCAGON-LIKE PEPTIDE I FRAGMENT 7-36 AMIDE HUMAN
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The Uses of GLUCAGON-LIKE PEPTIDE I FRAGMENT 7-36 AMIDE HUMAN
Glucagon-Like Peptide-1 is used as a Effector in the hormonal control of insulin secretion. The peptide fragment is secreted from the lower small intestine. Its action is mediated by receptors expressed by the endocrine pancreatic B-cells.
The Uses of GLUCAGON-LIKE PEPTIDE I FRAGMENT 7-36 AMIDE HUMAN
Glucagon-Like Peptide (GLP) I Amide Fragment 7-36 human has been used as a GLP-1 receptor agonist:
- in lysate transfer cyclic adenosine monophosphate (cAMP) assay to test its effect on adenylyl cyclase activity
- to pre-treat the human umbilical vein endothelial cells (HUVECs) to monitor its effect on hyperpermeability in endothelial cell (EC) monolayers and changes with the actin cytoskeleton
- to test its inhibitory effect on vascular endothelial growth factor-A (VEGFA) based vasodilation in rat mesenteric arteries
What are the applications of Application
Glucagon-Like Peptide 1 (7-36) Amide is a potent insulinotropic peptide
General Description
Glucagon-like peptide 1 (GLP-1) peptide is obtained from proglucagon and is metabolically inactive. However, it is processed to two smaller amide forms, namely GLP-1 (7-37) amide and GLP-1 (7-36) amide. It is a natural gastrointestinal peptide.
Biochem/physiol Actions
GLP-1 (glucagon-like peptide 1) (7-36) amide is a potent insulinotropic peptide, which initiates the glucose-induced insulin release after meals or oral glucose intake. It has an anti-diabetogenic effect and thus, might have use in the treatment of non-insulin dependent diabetes mellitus.
storage
Store at -20°C
Properties of GLUCAGON-LIKE PEPTIDE I FRAGMENT 7-36 AMIDE HUMAN
Density | 1.47 |
RTECS | LZ3980060 |
storage temp. | −20°C |
solubility | Soluble in DMSO |
form | powder |
Water Solubility | Soluble in water (1 mg/ml). |
Safety information for GLUCAGON-LIKE PEPTIDE I FRAGMENT 7-36 AMIDE HUMAN
Computed Descriptors for GLUCAGON-LIKE PEPTIDE I FRAGMENT 7-36 AMIDE HUMAN
InChIKey | DTHNMHAUYICORS-KTKZVXAJSA-N |
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