Gefitinib-d6
- CAS NO.：1228664-49-0
- Empirical Formula: C22H24ClFN4O3
- Molecular Weight: 446.91
- MDL number: MFCD21363632
- Update Date: 2025-08-21 22:16:43
What is Gefitinib-d6?
Description
Gefitinib-d6 is intended for use as an internal standard for the quantification of gefitinib by GC- or LC-MS. Gefitinib is an EGFR inhibitor (IC50s = 0.023-0.079 μM). It inhibits colony formation of GEO colon, ZR-75-1 and MCF-10A breast, and OVCAR-3 ovarian cancer cell lines in soft agar assays (IC50s = 0.2-0.4 μM). Gefitinib (0.1 to 1 μM) induces apoptosis and inhibits EGFR autophosphorylation in the same cells. In vivo, gefitinib (1.25, 2.5, and 5 mg/kg) reduces tumor volume and increases survival in a GEO mouse xenograft model. Formulations containing gefitinib have been used in the treatment of non-small cell lung cancer (NSCLC).
The Uses of Gefitinib-d6
Gefitinib-d6 is the labeled version of Gefitinib (G304000), which is an antineoplastic.
Properties of Gefitinib-d6
| storage temp. | Store at -20°C |
| solubility | DMF: 20 mg/ml,DMSO: 20 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml,Ethanol: 0.3 mg/ml |
| form | A solid |
| color | White to off-white |
Safety information for Gefitinib-d6
Computed Descriptors for Gefitinib-d6
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