4-(3-Chloropropyl)morpholine
- CAS NO.：7357-67-7
- Empirical Formula: C7H14ClNO
- Molecular Weight: 163.65
- MDL number: MFCD00039714
- EINECS: 461-510-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-03-25 14:24:00
What is 4-(3-Chloropropyl)morpholine?
Description
4-(3-Chloropropyl)morpholine is a hydrochloride salt of the potent inhibitor 4-(3-chloropropyl)morpholine. It has an inhibitory effect on cancer, and is used in chromatographic science to separate amines from aliphatic hydrocarbons. 4-(3-Chloropropyl)morpholine inhibits epidermal growth factor (EGF) and has been shown to have a potent inhibitory effect on EGF receptor tyrosine kinase activity. It also inhibits the proliferation of cells by inhibiting DNA synthesis. This compound causes cell death through the inhibition of protein synthesis, which may be due to its ability to inhibit nucleophilic reactions that are involved in protein synthesis. 4-(3-Chloropropyl)morpholine can also fluoresce under UV light, which makes it useful for research purposes.
Chemical properties
Pale Yellow Oil
The Uses of 4-(3-Chloropropyl)morpholine
Gefitinib intermediate
The Uses of 4-(3-Chloropropyl)morpholine
Gefitinib intermediate.
What are the applications of Application
4-(3-Chloropropyl)morpholine is an intermediate of Gefitinib
What are the applications of Application
4-(3-Chloropropyl)morpholine is an organic synthetic reagent or pharmaceutical intermediate used in the synthesis of gefitinib. It has cancer-inhibiting properties and inhibits epidermal growth factor (EGF). It also inhibits cell proliferation by inhibiting DNA synthesis.
Properties of 4-(3-Chloropropyl)morpholine
| Melting point: | NA |
| Boiling point: | 115°C/25mmHg(lit.) |
| Density | 1.0409 g/cm3 |
| RTECS | QE0488000 |
| refractive index | 1.4720-1.4760 |
| Flash point: | 91 °C |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Oil |
| pka | 7.03±0.10(Predicted) |
| color | Colourless to Yellow |
| Specific Gravity | 1.08 |
| InChI | InChI=1S/C7H14ClNO/c8-2-1-3-9-4-6-10-7-5-9/h1-7H2 |
| CAS DataBase Reference | 7357-67-7(CAS DataBase Reference) |
Safety information for 4-(3-Chloropropyl)morpholine
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for 4-(3-Chloropropyl)morpholine
| InChIKey | PQECODMSWJOUAT-UHFFFAOYSA-N |
| SMILES | N1(CCCCl)CCOCC1 |
4-(3-Chloropropyl)morpholine manufacturer
VINEET LABORATORIES LIMITED
1Y
Phone:+919642200049
Whatsapp: +91 9642200049
product: 4-(3-chloropropyl) morpholine 7357-67-7 98%
SVK Laboratories Pvt Ltd
1Y
Phone:+91-9177729915
Whatsapp: +91 9177729915
product: 3-Morpholinopropylchloride 98%
Lakshmi Farmachem
1Y
Phone:+91-9550886476
Whatsapp: +91-9550886476
product: 3-Morpholinopropylchloride 98%
Synergene Active Ingredients Pvt. Ltd.
1Y
Phone:+91-04023700774
product: 3-Morpholinopropylchloride 98%
Rivashaa Agrotech Biopharma Pvt. Ltd.
1Y
Phone:+91-7926462688
product: 3-Morpholinopropylchloride 7357-67-7 98%
Glyra Health Care Pvt Ltd
Phone:+91-9727720767
Whatsapp: +91-9727720767
product: 7357-67-7 3-Morpholinopropylchloride 99%
Sibram Pharmaceutical
1Y
Phone:+91-8655777550
Whatsapp: +91-8655777550
product: 7357-67-7 3-Morpholinopropylchloride 99%
Archerchem Healthcare Pvt., Ltd. (part of Archerchem Group)
Maharashtra
product: 3-Morpholinopropylchloride
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