4-(3-Chloropropyl)morpholine

CAS NO.：7357-67-7
Empirical Formula: C7H14ClNO
Molecular Weight: 163.65
MDL number: MFCD00039714
EINECS: 461-510-0
SAFETY DATA SHEET (SDS)
Update Date: 2024-03-25 14:24:00

What is 4-(3-Chloropropyl)morpholine?

Description

4-(3-Chloropropyl)morpholine is a hydrochloride salt of the potent inhibitor 4-(3-chloropropyl)morpholine. It has an inhibitory effect on cancer, and is used in chromatographic science to separate amines from aliphatic hydrocarbons. 4-(3-Chloropropyl)morpholine inhibits epidermal growth factor (EGF) and has been shown to have a potent inhibitory effect on EGF receptor tyrosine kinase activity. It also inhibits the proliferation of cells by inhibiting DNA synthesis. This compound causes cell death through the inhibition of protein synthesis, which may be due to its ability to inhibit nucleophilic reactions that are involved in protein synthesis. 4-(3-Chloropropyl)morpholine can also fluoresce under UV light, which makes it useful for research purposes.

Chemical properties

Pale Yellow Oil

The Uses of 4-(3-Chloropropyl)morpholine

Gefitinib intermediate.

The Uses of 4-(3-Chloropropyl)morpholine

Gefitinib intermediate

What are the applications of Application

4-(3-Chloropropyl)morpholine is an intermediate of Gefitinib

What are the applications of Application

4-(3-Chloropropyl)morpholine is an organic synthetic reagent or pharmaceutical intermediate used in the synthesis of gefitinib. It has cancer-inhibiting properties and inhibits epidermal growth factor (EGF). It also inhibits cell proliferation by inhibiting DNA synthesis.

Properties of 4-(3-Chloropropyl)morpholine

Melting point:	NA
Boiling point:	115°C/25mmHg(lit.)
Density	1.0409 g/cm3
RTECS	QE0488000
refractive index	1.4720-1.4760
Flash point:	91 °C
storage temp.	Inert atmosphere,Store in freezer, under -20°C
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Oil
pka	7.03±0.10(Predicted)
color	Colourless to Yellow
Specific Gravity	1.08
InChI	InChI=1S/C7H14ClNO/c8-2-1-3-9-4-6-10-7-5-9/h1-7H2
CAS DataBase Reference	7357-67-7(CAS DataBase Reference)

Safety information for 4-(3-Chloropropyl)morpholine

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.