GANODERIC ACID A
Synonym(s):(2R,6R)-6-[(5R,7S,10S,13R,14R,15S,17R)-7,15-dihydroxy-4,4,10,13,14-pentamethyl-3,11-dioxo-2,5,6,7,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-methyl-4-oxoheptanoic acid;(7β,15α,25R)-7,15-Dihydroxy-3,11,23-trioxo-lanost-8-en-26-oic acid
- CAS NO.:81907-62-2
- Empirical Formula: C30H44O7
- Molecular Weight: 516.67
- MDL number: MFCD26131275
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-08-21 17:50:07
What is GANODERIC ACID A?
Description
Ganoderic acid A is a triterpene that has been found in Ganoderma and has diverse biological activities. It reduces cell viability, expression of superoxide dismutase 1 (SOD1), SOD2, and SOD3, and production of reactive oxygen species (ROS) in PC3 prostate cancer cells. Ganoderic acid A (2-100 μg/ml) reduces hypoxia-induced apoptosis in H9c2 cardiomyocytes. It inhibits LPS-induced activation of NF-κB, release of TNF-α, IL-1β, and IL-6, and mitochondrial activity in primary mouse cortical microglia. Ganoderic acid A (20 and 40 mg/kg) reduces lung myeloperoxidase (MPO) activity, neutrophil infiltration, and NF-κB signaling, as well as bronchoalveolar lavage fluid (BALF) levels of TNF-α, IL-1β, and IL-6 in a mouse model of LPS-induced lung injury. It also reduces weight gain and hepatic lipid accumulation and improves insulin sensitivity in a mouse model of high-fat diet-induced obesity.
Chemical properties
White powder
The Uses of GANODERIC ACID A
Ganoderic Acid A, is a new lanostanoid triterpene extracted from the fruit bodies of Ganoderma Lucidum mushroom. these compounds are shown to possess many therapeutic properties. They can be used as anti-virus, anti-inflammation, anti-tumor, immunity-promoting, anti-diabetic, etc.
Definition
ChEBI: Ganoderic acid A is a triterpenoid.
Properties of GANODERIC ACID A
Melting point: | 118~123℃ |
Boiling point: | 690.1±55.0 °C(Predicted) |
Density | 1.22 |
storage temp. | Sealed in dry,Store in freezer, under -20°C |
solubility | Chloroform (Slightly, Sonicated), Methanol (Slightly) |
form | Solid |
pka | 4.78±0.23(Predicted) |
color | White to Pale Yellow |
Safety information for GANODERIC ACID A
Computed Descriptors for GANODERIC ACID A
New Products
Tubulysin F Tubulysin C 2,2-diethoxyethanethioamide Tubulysin H (2S,4R)-4-amino-2-methyl-5-phenylpentanoic acid hydrochloride Potassium HMDS (1.0 M in THF) 1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE CYCLOBUTYLAMINE HYDROCHLORIDE 4-(Benzyloxy)-3-bromophenylacetic Acid Isoxazole, 3-[[[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]thio]-4,5-dihydro-5,5-dimethyl- 2-(azetidin-3-ylidene)acetonitrile (hydrochloride) 2,2-Difluoropropanol Imeglimin Hydrochloride IH 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol Fuel shell 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Calcium Sodium Phosphosilicate IH Magnesium Trisilicate Latanoprostene Bunod Lubiprostone Flame Retardant Zinc Borate methyl 3-fluoro-4- thiomorpholino phenylcarbamate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonateRelated products of tetrahydrofuran
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