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HomeProduct name listGANODERIC ACID A

GANODERIC ACID A

Synonym(s):(2R,6R)-6-[(5R,7S,10S,13R,14R,15S,17R)-7,15-dihydroxy-4,4,10,13,14-pentamethyl-3,11-dioxo-2,5,6,7,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-methyl-4-oxoheptanoic acid;(7β,15α,25R)-7,15-Dihydroxy-3,11,23-trioxo-lanost-8-en-26-oic acid

GANODERIC ACID A Structural

What is GANODERIC ACID A?

Description

Ganoderic acid A is a triterpene that has been found in Ganoderma and has diverse biological activities. It reduces cell viability, expression of superoxide dismutase 1 (SOD1), SOD2, and SOD3, and production of reactive oxygen species (ROS) in PC3 prostate cancer cells. Ganoderic acid A (2-100 μg/ml) reduces hypoxia-induced apoptosis in H9c2 cardiomyocytes. It inhibits LPS-induced activation of NF-κB, release of TNF-α, IL-1β, and IL-6, and mitochondrial activity in primary mouse cortical microglia. Ganoderic acid A (20 and 40 mg/kg) reduces lung myeloperoxidase (MPO) activity, neutrophil infiltration, and NF-κB signaling, as well as bronchoalveolar lavage fluid (BALF) levels of TNF-α, IL-1β, and IL-6 in a mouse model of LPS-induced lung injury. It also reduces weight gain and hepatic lipid accumulation and improves insulin sensitivity in a mouse model of high-fat diet-induced obesity.

Chemical properties

White powder

The Uses of GANODERIC ACID A

Ganoderic Acid A, is a new lanostanoid triterpene extracted from the fruit bodies of Ganoderma Lucidum mushroom. these compounds are shown to possess many therapeutic properties. They can be used as anti-virus, anti-inflammation, anti-tumor, immunity-promoting, anti-diabetic, etc.

Definition

ChEBI: Ganoderic acid A is a triterpenoid.

Properties of GANODERIC ACID A

Melting point: 118~123℃
Boiling point: 690.1±55.0 °C(Predicted)
Density  1.22
storage temp.  Sealed in dry,Store in freezer, under -20°C
solubility  Chloroform (Slightly, Sonicated), Methanol (Slightly)
form  Solid
pka 4.78±0.23(Predicted)
color  White to Pale Yellow

Safety information for GANODERIC ACID A

Computed Descriptors for GANODERIC ACID A

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