GANODERIC ACID DM
- CAS NO.:173075-45-1
- Empirical Formula: C30H44O4
- Molecular Weight: 468.67
- MDL number: MFCD04039843
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:11
What is GANODERIC ACID DM?
Definition
ChEBI: Ganoderic acid DM is a triterpenoid.
Biological Activity
Ganoderic acid DM is a triterpenoid that has been found in G. lucidum and has diverse biological activities. 1,2,3 It inhibits 5α-reductase and HMG-CoA reductase (IC50s = 10.6 and 9.5 μM, respectively) and binds to the ligand-binding domain of the androgen receptor in a fluorescence polarization assay.1,2 Ganoderic acid suppresses osteoclastogenesis of RAW 264.7 cells when used at a concentration of 12.5 μM and is cytotoxic to K562 leukemia and PC3 prostate cancer cells (IC50s = 18.8 and 81.6 μM, respectively). It reduces ear edema induced by phorbol 12-myristate 13-acetate in mice (ID50 = 0.08 mg/ear).3
References
1.Liu, J., Shiono, J., Shimizu, K., et al.Ganoderic acid DM: Anti-androgenic osteoclastogenesis inhibitorBioorg. Med. Chem. Lett.19(8)2154-2157(2009) 2.Wang, K., Bao, L., Xiong, W., et al.Lanostane triterpenes from the Tibetan medicinal mushroom Ganoderma leucocontextum and their inhibitory effects on HMG-CoA reductase and α?glucosidaseJ. Nat. Prod.78(8)1977-1989(2015) 3.Akihisa, T., Nakamura, Y., Tagata, M., et al.Anti-inflammatory and anti-tumor-promoting effects of triterpene acids and sterols from the fungus Ganoderma lucidumChem. Biodivers.4(2)224-231(2007)
Properties of GANODERIC ACID DM
storage temp. | -20°C |
solubility | Methanol: soluble |
form | Powder |
color | White to off-white |
Safety information for GANODERIC ACID DM
Computed Descriptors for GANODERIC ACID DM
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