GALANTHAMINONE
- CAS NO.：510-77-0
- Empirical Formula: C17H19NO3
- Molecular Weight: 285.34
- MDL number: MFCD08063719
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:09
What is GALANTHAMINONE?
Description
This alkaloid occurs in several families of the Amaryllidaceae and is obtained as colourless prisms when crystallized from Me2CO. It is dextrorotatory with [α]25D + 100° (c 0.2, CHC13). It forms a crystalline picrate, m.p. 123°C; a methiodide, m.p. 195-6°C and a semicarbazone, indicative of a keto group, m.p. 240-1 °c (dec.).
Chemical properties
White to Off-White
The Uses of GALANTHAMINONE
A metabolite of Galanthamine, a selective acetylcholinesterase inhibitor
The Uses of GALANTHAMINONE
Narwedine is the biogenetic precursor of galanthamine, has been studied as a respiratory stimulator. It increases the amplitude and decreases the frequency of cardiac contractions and would therefore be of value in reducing blood loss during surgery. It also inhibits the action of narcotics and hypnotics, and increases the analgesic effect of morphine as well as the pharmacological effects of caffeine, carbazole, arecoline, and nicotine.
Definition
ChEBI: Narwedine is a benzazepine.
References
Boit, Dapke, Beitner., Chem. Ber., 90,2197 (1957)
Properties of GALANTHAMINONE
| Melting point: | 175-180°C (dec.) |
| Boiling point: | 397.4±42.0 °C(Predicted) |
| Density | 1.28±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | DMSO : 10 mg/mL (35.05 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble) |
| form | Cryst. |
| pka | 7.84±0.20(Predicted) |
| color | White to off-white |
Safety information for GALANTHAMINONE
Computed Descriptors for GALANTHAMINONE
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